Carl, when I used Cypro on Tashie, it was almost immediately. I preferred the Cypro over the Mirtrazapine as you could doe every 12 hours with the Cyrpo and with the Mirt, every 72 hours and it would have some "wear off" - also, the Mirt seemed to make her "high" but not the Cypro. I would definitely say by the 2nd dose, it's kicked in. Are you giving it orally or transdermal?
Thinking of you & Bob and sending loads of eating vibes!
Bern