Antacid Therapy - H2-receptor antagonists (ranitidine or famotidine) or proton-pump inhibitors (pantoprazole) are not routinely recommended but should be considered if thereis concern for gastrointestinal ulceration.
Proton pump inhibitors (eg, omeprazole 0.5–1 mg/kg/day, PO, or pantoprazole 0.5–1 mg/kg/day, IV) offer more complete inhibition of gastric acid secretion and are therefore useful for more severe ulcers. Prophylactic use of H2 blockers and proton pump inhibitors to prevent GI ulceration is controversial but may be considered in animals receiving NSAIDs or that have other risk factors.