It's really quite difficult to tell as he's so new to Lantus. Though I don't think I'd shoot that 100 given how sensitive he is to insulin...or not at night anyway. You might want to try shooting one of the lower numbers (maybe around a 150 if he gets to that as a pre-shot) on his AM cycle to see what happens with it - he might do just fine, or he might earn a reduction straight away. I would leave it for an AM cycle though to make sure there are plenty of people around to help...unfortunately, I'm starting a work contract for a few weeks early on Tuesday morning so won't be able to stick around quite as late at night as I could last week.