hi - i saw your post on the high dose forum about you thinking grayson might have a high dose condition. took a look at grayson's ss. i don't know pzi dosing, so maybe i'm off on this, but on the off-chance that it's helpful to you i thought i'd throw some thoughts out anyway.
as well as high dose conditions, any cat can develop what's called glucose toxicity. it's basically a tolerance to insulin that's caused by the cat being in too high of BG numbers for too long. the more grayson is in high numbers, the more resistant to insulin he might become. that's not the same as iaa, which is when the body develops anti-bodies to the insulin.
just now bumped up the post on glucose toxicity so you can do some reading about it. whether or not grayson has a high dose condition, the basic tactic would be to become more aggressive on dose increases so that his BG gets knocked down into better ranges. there is some evidence that by keeping a cat's BG in lower numbers, it may keep the dose down. i can see you're increasing his dose, and as i said, i don't know PZI dosing so don't know if that's aggressive or not. if you were using lantus or lev, following the protocol, with grayson's current BG numbers, we'd suggest increasing by .5u every 4 cycles until we were seeing some green numbers. then we would slow down with the increases.
i don't want to butt in - every insulin support group has their own way of doing things, but because i saw your post over in the high dose forum (which is basically inactive) i thought i'd chase you down and post. there are several of us with high dose kitties using both lev and lantus in the TR forum. if you want help, just say so. :YMHUG:
