Meadow looks like she has nice flat cycles, so the dose might actually be ok. See Jazzy's spreadsheet, how she stays nice and flat when I shoot blue? What do you think about stalling for 30 minutes without feeding, to see if she is rising or falling or surfing?
There are a couple of ways to look at this number, if she's like Jazzy and she stays flat then shooting 22 units here is fine, in theory. The other is that Meadow's acro tumor is in a "rev down" (not producing as much growth hormone) so her dose might need to be reduced. This is where acro dosing gets tricky, because it's a "know thy cat" thing and you haven't been doing this long enough to know your cat that well yet. To be safe, I would stall a little and then if she's a bit higher or the same I would shoot. Shoot whatever dose makes you comfortable. This will help us collect data for next time.
Do you have lots of high carb wet food on hand?