Hello! Armani's blood glucose numbers have finally come down once I got some advice on here about increasing his dose. He is an acromegaly cat, and has been doing ok with about 27 units twice a day, but his numbers are getting too low. His spreadsheet is all updated if anyone can take a look. The past few days he's been under or around 50, but has been acting fine. I've been getting up in the middle of the night to test him and give him a little high carb kibble if he tests under 50 during the night. I have been giving a shot that's been reduced by a unit or so each time, so we've come down gradually to 22, but still this morning, he was the lowest ever (38) and for the first time showed symptoms of hypoglycemia, seeming disoriented and wobbly. I fed him and he ate normally, his normal friskies, also some high carb kibble and a little chicken baby food with a bit of honey mixed in. He seemed to feel better right away, and I have not given insulin, but his numbers are still in the 40s and aren't coming up though I've given him a few more bites of high carb kibble throughout the morning (I've tested a few times and this is being written about 4 hours after his breakfast). I'm pretty worried. (EDITED TO ADD: we are up to about 5 hours after breakfast and I just tested, he is 100) Lately in general his numbers aren't raising as much after food as they used to. I have some questions if anyone has the time to look them over: 1) I'll keep a close eye on him, keep giving him bites of high carb kibble, but I'm wondering what I should do otherwise. At what point today do I give insulin, and what dose? Assuming he comes up into the 70s or 80s, I was thinking a half dose? At this point should I wait until his dinner shot? What about a dose tomorrow? 2) At what number should insulin not be given? Is 50 the limit, as long as one is around to keep an eye on him? 3) For regulation, are we aiming to keep their blood between 50-100 (nadir)? 4) With acromegaly, is it normal for their insulin needs to change suddenly and dramatically, both up and down? 5) If this happens again and he starts getting too low, should I reduce the dose more dramatically than one unit at a time since his dose is so high? Since it is a depot insulin, it seems like dose changes take a long time to kick in, and his blood sugar numbers can be widely changing, which makes me unsure what to do. 6) At what number will a cat have hypoglycemia? Does it vary by the cat? Thank you very much for the help!!