OK if I remain with the current dose (2.50) I should be prepared for sub 50's the next two cycles.
Since the DEPOT is realigning with the current dose of 2.50 the likelihood of sub 50's event could be diminishing?
What would you recommend to reduce or stay the course
I don’t know the answer to your first question. That’s because Henry appears to be on a mission but, since it’s just been three cycles since the last reduction, it’s possible it’s depot and the likelihood of the sub 50s occurring again is less.
In regard to the second question, I’m torn

You are there and testing to keep him safe and it was just the third dose after his last reduction. He’s continued to run fairly low so that makes me believe the depot from 2.75u is still working.
However, Henry is usually carb sensitive and you’ve been feeding him 22% for a while and he’s only come up ~25. If it was depot, which should be waning, the 22% should have worked faster. I don’t want you to have to do a lot of feeding and poking again tomorrow trying to keep him above 50.
If cycle 4 plays out the same way it is currently doing in cycle 3 could reduce at cycle 5?
Absolutely.
I know I’ve been talking about not taking too many reductions too fast; the flip side is safety and I always err on that side. So, my tendency,
in this situation, would be to reduce the dose in the morning to 2.25u. You can always take him back up.
Those are my thoughts but you are the one doing this and I support your decision either way.