bluesunshine
Very Active Member
Yesterday
@Wendy&Neko: Would you still recommend an increase to 8 units tonight? She's still on this weird multi-cycle-with-a-single-nadir thing
. Today's bounce does seem shallower than the previous two, with her potentially dipping into greens early this morning (which i missed). I am also not sure if I should increase on the PM cycle since that is the one that has broken into an early morning nadir 3 times in a row.
Guessing an increase would flatten her out.
I've been reading through a bunch of IAA info, and had a question about this statement. If I understand correctly, the potential extended half-life of the insulin isn't that the unbound insulin lasts longer it is that some of the bound insulin can eventually be "unbound" and start doing their insulin normal thing. Is that accurate?
That leads me to another question: Do insulin molecules ever die/become permanently inactive? Like if an insulin molecule is bound for a long enough period of time by an auto-antibody, will it cease to be able to be effective if released? Or is all this insulin bound up by these auto-antibodies just waiting to help glucose enter other cells upon release?
@Wendy&Neko: Would you still recommend an increase to 8 units tonight? She's still on this weird multi-cycle-with-a-single-nadir thing

Guessing an increase would flatten her out.
IAA can lead to an increase in the half-life of free (unbound) insulin in circulation because some bound insulin gets released into circulation. The increase in half-life can lead to prolongation of action.
I've been reading through a bunch of IAA info, and had a question about this statement. If I understand correctly, the potential extended half-life of the insulin isn't that the unbound insulin lasts longer it is that some of the bound insulin can eventually be "unbound" and start doing their insulin normal thing. Is that accurate?
That leads me to another question: Do insulin molecules ever die/become permanently inactive? Like if an insulin molecule is bound for a long enough period of time by an auto-antibody, will it cease to be able to be effective if released? Or is all this insulin bound up by these auto-antibodies just waiting to help glucose enter other cells upon release?