With acros, it really does come down to knowing thy cat, even more so. I think for a lot of acros, shooting low really does produce flat and steady cycles. As long as the cat is eating.
I also have a problem with what to suggest if a person balks from shooting the 50’s and 60’s and there is such a large depot. If they shoot a reduced dose, that depot is running the show. Stalling is one option, as long as the cat goes up. If they don’t, you are stuck. Shooting low really gives you the opportunity to see if that dose is too much. If you stall or shoot a reduced dose, or worse skip, then you may not find out if the dose is too high. And you will be stuck with an overfull large depot.