Your tag didn't work, but I happened to be looking at posts here.
What dosing method are you following? It says "do not copy dosing", but I need a general idea in order to help you with dosing. You also need to hold the same dose at least six cycles so we can see what it's doing. You don't need to reduce the dose for a perfectly safe to shoot number in the 200's. Remember, we determine how to change the dose based on nadirs, or how low the dose takes the cat, not preshots. I rather suspect Buddy will need another increase but let's see what six units can do first.
Tonight's wonky number could be just a reaction to the depot getting unstable with the reduced dose yesterday.