Vet says "not diabetic" - but Glucose seems high to me?

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Alberta_Girl

Member Since 2023
Hello,
I was in this group many years ago when I had my Diabetic boy Taco.

I have a 17 yr old spayed female indoor kitty who has always been very healthy and spunky, even still for her age. About Oct 18/23 she started throwing up small amounts of clear throw-up mostly with a bit of foamy in it. She seemed a little off, not even interested in treats, so I was able to get her into the Vet. They did abd xrays and full bloodwork including fPL for pancreatitis and thyroid, an urinalysis, too. Spec fPL came back elevated at 22 (range is 0.0 - 4.4, Idexx). Kidneys great (BUN, creat, SDMA), liver great, CBC great, gluclose was a little high at 10.3 (Idexx range 4.0 - 9.7) but that was attributed to her great stress being at the vet and having blood drawn. Urinalysis showed no infection, no glucose, no ketones, specific gravity a little dilute at 1.018. She was obvious diagnosed w/ Pancreatitis and sent home on Cerenia for 3 days. Vet said an abdominal ultrasound would be beneficial but sadly I just don't have $1200 for that (what it costs where I am).

She was fine after that, until Nov 22, vomited once but then fine until Dec 6, started vomiting again (clearish liquid mostly and some digested canned food, small amounts of vomit mostly), seen again, was given an injection of Cerenia and one of Bupronephrine (sp?) as her belly seemed a bit tender they said. Vet Tech thought her gums were not as slippery as they could be and her scruff skin tenting was a bit slow (I disagreed with the first, gums were slippery to me and in older cats their skin tent is a bit sluggish returning to position due to loss of skin elasticity?) so she told me to give 100cc of S/C fluids a day for 3 days. I found that too much so I gave 100 cc that night then 2 nights later. Vet thought maybe chronic pancreatitis or a flare up?

Of course when she vomits, she hangs out at the water dish a lot and makes frequent trips to the water dish which I think is normal w/ nausea/vomiting in cats.

Dec 18 she started vomiting again, so they gave me a shot of Cerenia to give her which I did. Always works like a charm. That evening I decided to start giving her 2.5 mg of Pepcid AC every evening because sometimes I wonder if her throwing up is a gastritis....as there are times she'll throw up clear liquid then head to her food bowl and eat a bunch of canned and keep it down.....

Today, Dec 23, could tell she wasn't as hungry this morning and then she started throwing up. In the event this is chronic pancreatitis, I was doing some reading up on it and read that a course of corticosteroids can help decrease the inflammation, thought maybe I'd talk to Vet about this. But decided to check her BG at home here with my human glucose meter. First time it was 10.5 mmol/l, did it again 15 min later, 10.0 mmol/l. That kind of shocked me. I'm in Canada so our glucose meters measure in mmol/l. I converted that to md/dl, that's about 180.

From what I've read sometimes Pancreatitis can cause a temporary elevation in glucose, also pancreatitis can sometimes damage the beta cells in the pancreas leading to diabetes.


I was able to get her into a much more affordable Vet (plus our main one closed for the holidays).
I show this Vet her full labwork from Oct 20th, give him the above history. I told him that I think she's diabetic as her BG was about 10 (180). He disagreed with me. He said because the range from Idexx (when blood run at the lab) is 4.0 - 9.7, her being only 10 is not a big deal, it could a bit over the high end of the Idexx lab range because of the vomiting she had today (??) and that she's def not diabetic. For the record, she is the most sweet mellow cat so was not the least bit stressed out by me poking her ear flap to get the little drop of blood to test her with the meter.

This confuses me. I even told him that I've had a diabetic cat years ago (he was diabetic for 6 years, ended up getting him very well controlled on Levemir, he passed due to cancer sadly) and from what I've read, normal BG in a non-diabetic cat is like 4.4 -6.6 from what I've read. I told him that 10 mmol/L is 180 mg/dl and that seems high to me, he assured me it was not high enough to be considered diabetic.

He gave her a shot of Cerenia and sent me home with some extra shots as needed. He was very nice and kind but I left there feeling concerned that she IS diabetic...and maybe that's what's causing the ongoing, although intermittent vomiting? I had even asked him about the latter but he said the vomiting was likely due to possible chronic pancreatitis or maybe even IBD.

She eats mostly all canned food......stuff that's lower carb variety (fancy feast, friskies), maybe the odd nibble of dry food (which I will take away now as I'm sure it's very high in carbs) so it's not like a diet change to something lower carb is going to improve anything.

I gotta admit, I was shocked that he was so sure her BG at home of 10 (180) is not considered diabetic. It just goes against everything I remember and even what I still read online now from reputable feline diabetic resources. How could he not know what a BG high enough to indicate diabetes in a cat is? Isn't this basic Vet 101 stuff?

All I can do is try to save up the $500 (Vet care where I live is insanely expensive), which will take time, to take her in for bloodwork again.....perhaps just a blood glucose and urinalysis (run by Idexx)....but I fear then if it's elevated he'll just attribute it to stress at the Vet and still say she's not diabetic.

I will admit, when my old boy Taco was diagnosed, his BG the first time I did it was super super high, like 350 or 380? (can't remember now) so it was a no-brainer.

She has not lost any weight at all in fact she's gained a 1/2 pound in the past 2 months (she's now 10.5 lbs) which, I admit, is a bit odd if she was really diabetic because they generally lose weight. She eats like a little piggy....though frequent small amounts through the day (canned). She'll take your finger off for a cat treat LOL.

I should add, I obviously didn't ask about a course of corticosteroid (prednisilone) because that would be dangerous if she actually IS diabetic.

Sorry this is so long but I'm wanting to give the full picture.

Hugs
Alberta_Girl
 
Waving Hi from the province towards the coast from you.

Not sure if you've read this one yet: A Primer On Pancreatitis Pancreatitis can be painful, she may need more than just 1 shot of buprenorphine, maybe some to take home and give for a while? Pain can also increase blood sugar numbers. Hanging out by the water dish is a sign of nausea. You might want to see if you can get a prescription for ondansetron from the vet. It's a human drug, you take the script to a regular pharmacy to get it filled. I find ondsetron better than Cerenia for nausea, though Cerenia is better for vomitting. You can give both.

Inflammation (such as from pancreatitis) or infection can definitely elevate the BG, as can stress. Neko's buddy once tested over 220 at the vet due to stress and a cystitis episode. Once resolved (ie. next day at home), he was down to 53. 180 is not that high a number with other things at play. What type of meter are you using to test with? Idexx range at the labs isn't a straight comparison with what you read on a human BG meter. It is probably closer to what is on a pet meter which has a higher number at the upper range of normal.

Was a fructosamine run? Without that and a positive urine glucose, I wouldn't be calling it diabetes just yet. Diabetes by itself doesn't usually cause vomiting. The pancreatitis or IBD would have been my guess too.
 
Waving Hi from the province towards the coast from you.

Not sure if you've read this one yet: A Primer On Pancreatitis Pancreatitis can be painful, she may need more than just 1 shot of buprenorphine, maybe some to take home and give for a while? Pain can also increase blood sugar numbers. Hanging out by the water dish is a sign of nausea. You might want to see if you can get a prescription for ondansetron from the vet. It's a human drug, you take the script to a regular pharmacy to get it filled. I find ondsetron better than Cerenia for nausea, though Cerenia is better for vomitting. You can give both.


Inflammation (such as from pancreatitis) or infection can definitely elevate the BG, as can stress. Neko's buddy once tested over 220 at the vet due to stress and a cystitis episode. Once resolved (ie. next day at home), he was down to 53. 180 is not that high a number with other things at play. What type of meter are you using to test with? Idexx range at the labs isn't a straight comparison with what you read on a human BG meter. It is probably closer to what is on a pet meter which has a higher number at the upper range of normal.

Was a fructosamine run? Without that and a positive urine glucose, I wouldn't be calling it diabetes just yet. Diabetes by itself doesn't usually cause vomiting. The pancreatitis or IBD would have been my guess too.

Iam no expert by all means, when they loose appetite or they skip 1 or two meals, I have a tube of Miratz this in an ointment placed on the inside of upper ear, within 1 hour they devour their meal it is prescribed not too expensive here in Miami FL., is $37.99 small tube goes a long way. I as well I cannot afford not even one Dr's visit, sometimes they exaggerate, not properly diagnose, like diabetes, I have not visited a Vet since Corky was diagnosed this Forum has walked me thru this illness all the way, never have gone wrong with my Corky's assistance of course, Corky is very very healthy, unless your kitty has other major illnesses that are serious it's different. I wish the best to you and your furr baby, remember as I said before, I am not an expert, but I've had to seek alternative resources, This Forum first, and home remedies and they work, searched the web, they have home remedies, like for constipation there is, prescribed Lactulose or mineral oil, over the counter but This Forum will help you thru best to you have a wonderful Holiday full of Health and blessings for this New Year From Corky, Coco and me
:bighug::cat::cat:
 
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I agree with Wendy's observation that your cat's numbers may have been elevated either from an inflammation such as pancreatitis or from pain. Any infection or inflammation is a source of stress and can raise blood glucose levels. I'd get some readings when your kitty is back to normal behavior. I do agree with you though, that numbers in the 180s are outside of normal range. A fructosamine test would also be helpful.
 
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Please do not give your cat paregoric. First, I don't even know that you can get "real" paregoric over the counter. It's a narcotic (or a narcotic derivative -- at least what Maria is mentioning) that is used for diarrhea. I have NEVER seen it used with cats and I've been on this board for almost 15 years.

I agree with Wendy's observation that your cat's numbers may have been elevated either from an inflammation such as pancreatitis or from pain. Any infection or inflammation is a source of stress and can raise blood glucose levels. I'd get some readings when your kitty is back to normal behavior. I do agree with you though, that numbers in the 180s are outside of normal range. A fructosamine test would also be helpful.

My strongest apology if I mislead the member, these drops are given even to a baby whith colic or indigestion it is not a narcotic it is bought over the counter I gave it for 14 years if needed to my teacup yorkie recommend by the vet and for my kids by the Pediatrician it helps stomach and digestion not a narcotic, it has been a minor remedy, passed on from family to family member, then again you know best what to do what not, will not speak of it in this forum again, if one looks up the definition online this is not the same at all sorry to step in:cat::cat:
 
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100 ml of fluids daily is actually fine for a 10.5 lb cat, especially if you're only doing them short-term and she's dehydrated. Dehydration increases blood glucose simply due to increased concentration of everything in the blood due to there being less water in the body to dilute. So you can't necessarily take the numbers you're getting as accurate until she is no longer dehydrated quite aside from any infection or inflammation also raising the levels. Dehydration will also make her feel more nauseous.

Do bear in mind with Pepcid AC that the newer research shows that giving it for more than 7 days causes it to become ineffective. In addition to this, there is a high chance of rebound reflux when you stop it. Omeprazole is seen as a better option currently.

Treatment for pancreatitis consists of fluids, pain meds, anti-nausea meds and an appetite stimulant if needed. If she was only given a shot of basic bup, that only really lasts 12 hours. Bup SR works for 3 days. So it's important to know which type she was given. If she only got regular bup, I would be asking for some pain meds to have at home. Cerenia is only meant to be given for 5 days on/2 days off (I know the internet disagrees with this, but the manufacturer information has not changed and giving it for too long without breaks can cause issues) - if she's going to need longer-term support, Zofran may be a better option for you to discuss with your vet.
 
Cerenia is only meant to be given for 5 days on/2 days off (I know the internet disagrees with this
Its more than "just the internet". See (2016) ISFM Consensus Guidelines: Diagnosis & Management of Feline Chronic Kidney Disease table 9 page 232 and from the Journal of Vet Pharmacology and Theurapeutics Safety, pharmacokinetics and use of the novel NK-1 receptor antagonist maropitant (Cerenia) for the prevention of emesis and motion sickness in cats. You are correct that the oral form of the drug is technically off label for cats. But oral dosing has been studied other than just by the manufacturer. Would love to see any newer references if you have them.

@Alberta_Girl Different topic - do NOT buy or get a prescription for Zofran in Canada. The brand name (Zofran) is prohibitively expensive. The generic drug ondansetron is a much better price. And do shop around if you can. I've seen prices vary up to $1 per pill between stores for the same generic.
 
ts more than "just the internet". See (2016) ISFM Consensus Guidelines: Diagnosis & Management of Feline Chronic Kidney Disease table 9 page 232 and from the Journal of Vet Pharmacology and Theurapeutics Safety, pharmacokinetics and use of the novel NK-1 receptor antagonist maropitant (Cerenia) for the prevention of emesis and motion sickness in cats. You are correct that the oral form of the drug is technically off label for cats. But oral dosing has been studied other than just by the manufacturer. Would love to see any newer references if you have them.
It really isn't though. For the first study, they only gave it for 2 weeks. Longer-term administration hasn't been tested and isn't classed as safe. However, many people claim that the 2-week study means it can be given indefinitely. It doesn't. The second study doesn't say anything about dosing it daily long-term - just- that they gave it for 2 weeks. 2 weeks as a one-off situation is very different from 2 weeks now, then 2 weeks in another few days etc because Substance-P depletion is cumulative.
 
@manxcat419 - April -- could you please provide the references? You can PM me with the information. I have access to both medical and veterinary libraries so if the research is suggesting something different than what we recommend, I want to have the evidence to back up what we are telling people.
 
It is literally in the prescribing and usage information from Zoetis. It is only licensed and authorized for up to 5 days use at a time. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.zoetisus.com/content/_a...olution-Combined-Marketing-Package-Insert.pdf

Edited to add - the studies Wendy posted ONLY tested it for 2 weeks. This is not long-term in any way, shape or form, and to interpret it as a long-term safety study is inaccurate. Personally, I would like to see some actual backing for the constant claims on internet forums that it's safe for daily long-term use but no-one can provide those because 2 weeks is the longest it's been tested for.
 
@manxcat419 - Not to beg the issue but Lantus does not have an indication for cats. It's an off label use. Based on your rationale, we should not be utilizing this insulin in our cats. Vets are routinely prescribing Lantus and are routinely prescribing Cerenia for longer than 2 weeks.

If I had to speculate, it's likely that there have been conference presentations on this topic. There is not much in the literature regarding maropitant and cats. There is a larger literature pertaining to its use in dogs.
 
No. Just no. There is a world of difference between using something off-label and using it in a way that was never intended. When we use Lantus for cats (or any other of the myriad meds that are off-label for cats), we use them according to the known safety data. The known safety data on Cerenia demonstrates that long-term use can come with some very unpleasant side effects - some of which are not reversible. And yet, people persist in insisting that it can be used daily and indefinitely. The reason the literature all pertains to dogs for the oral version is because it's off-label for cats. So it's not being tested in that format in cats. However, long-term use of the injectable for cats is where you find those long-term side effects. The long-term side effects are the same for both the injectable and the oral for dogs (not surprising given that it's the same drug), so it is more than 99.9% likely that the same holds true for cats. There are not conference presentations on the topic - I work in vet med and have access to content that is not generally available. There is simply an assumption amongst some vets, which weirdly appears to be driven by owners, that it is "probably safe". Until you start seeing those irreversible neurological issues - and I've seen many, many people have cats with those thanks to this assumption that it's safe.
 
The long-term side effects are the same for both the injectable and the oral for dogs (not surprising given that it's the same drug), so it is more than 99.9% likely that the same holds true for cats
I beg to disagree in this point. Cats’ metabolism is very different than dogs and they are not physiologically identical species. There are many drugs which dogs can take but cats can’t and vice-versa. In addition, it can even come down to the individual animal just as medications in humans.

Insofar as long- term use of oral cerenia in cats, I did use it long-term in Gracie with no side effects but ECID. The decision on whether to use it long-term is between the CG and their vet after looking at the safety information, the specific chronic issues for which the cat needs it, QOL, etc. It’s not just black and white, April, and a good veterinarian knows that.
 
I beg to disagree in this point. Cats’ metabolism is very different than dogs and they are not physiologically identical species. There are many drugs which dogs can take but cats can’t and vice-versa. In addition, it can even come down to the individual animal just as medications in humans.

Insofar as long- term use of oral cerenia in cats, I did use it long-term in Gracie with no side effects but ECID. The decision on whether to use it long-term is between the CG and their vet after looking at the safety information, the specific chronic issues for which the cat needs it, QOL, etc. It’s not just black and white, April, and a good veterinarian knows that.
The actual observed side effects of Cerenia are the same in both dogs and cats. Physiologically different they may be, but that doesn't mean that every drug will interact differently between the 2 species. And...if we're going down that road, then oral Cerenia hasn't even been tested for 2 weeks in cats, so you're back to it needing to be used per the label instructions which is no more than 5 days at a time. Because that's all there is actual data for.

Thing is, the OP is already not taking the vet's advice. The fluid amount that was prescribed was already reduced because she decided it was too much even though it's within safe range. Her vet is also only doing the Cerenia injectable so there's that. I was obviously discussing in general terms. Obviously it's not always black and white, but I hear all the time on internet forums of cats that have been on Cerenia long-term and have suddenly developed tremors and twitching and where the CG refuses point-blank to even consider the long-term use of Cerenia as the likely cause. The risks of neurological damage need to be clearly understood and communicated rather than ignored when offering information to others. Especially when people are frequently so insistent that their vet (and any other vet too) are wrong and that they should get exactly what they want, when they want.
 
The actual observed side effects of Cerenia are the same in both dogs and cats. Physiologically different they may be, but that doesn't mean that every drug will interact differently between the 2 species. And...if we're going down that road, then oral Cerenia hasn't even been tested for 2 weeks in cats, so you're back to it needing to be used per the label instructions which is no more than 5 days at a time. Because that's all there is actual data for.

Thing is, the OP is already not taking the vet's advice. The fluid amount that was prescribed was already reduced because she decided it was too much even though it's within safe range. Her vet is also only doing the Cerenia injectable so there's that. I was obviously discussing in general terms. Obviously it's not always black and white, but I hear all the time on internet forums of cats that have been on Cerenia long-term and have suddenly developed tremors and twitching and where the CG refuses point-blank to even consider the long-term use of Cerenia as the likely cause. The risks of neurological damage need to be clearly understood and communicated rather than ignored when offering information to others. Especially when people are frequently so insistent that their vet (and any other vet too) are wrong and that they should get exactly what they want, when they want.
We don’t want to hijack this thread any longer. Perhaps the discussion is better for Think Tank.
 
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