Critter Mom
Member Since 2014
View attachment 15728 Jet says, "Genghis has been endorsed by the Black Cat Authority"
He's beautiful, Melanie!
On the two forms of insulin in Caninsulin, the amorphous part kicks in first and drops the BG fairly hard and fast after onset at the beginning of the cycle - typically between +1 and +2 - depends on how fast the individual cat metabolizes the insulin - and it takes the BG down to nadir, or close to it since it typically exerts peak effect between +3 and +6. The crystalline fraction gradually becomes available as the cycle progresses, and in some cats it may produce a second nadir later in the cycle as it overlaps the action of the remaining amorphous fraction. The manufacturer gives about +7 or thereabouts as the time when the crystalline fraction exerts maximum effect.
With regard to preparing Caninsulin prior to drawing up a dose, because part of the insulin is crystalline it tends to settle at the bottom of the vial. You need to mix Caninsulin gently so that the crystalline fraction is evenly distributed in the diluent thus enabling you to get the correct proportions of both amorphous and crystalline insulin in the drawn up dose.
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