Some kitties have what we call high dose conditions. The most common one is called acromegaly. It is the result of a benign tumour on the pituitary putting out excess growth hormone. Neko had it for her last five years. One in four diabetic cats has it. It can mean the need for larger doses. Neko got up to 8.75 units, some across need much more insulin and some less. A second high dose condition we see around here is called Insulin Auto Antibodies or IAA. Think of it like an allergy to the injected insulin. Neko also had it too. A third condition that we see a lot less often is called Cushings and it usually involves some skin conditions. There is a blood test to look for the first two conditions and a urine test for the third. Regardless, insulin needs can change over time and different cats need different amounts of insulin. We keep increasing until we find good numbers. Once kitties get into good numbers, they feel much better.