I still cast my vote for the .4u for a mid 200, maybe 0.3u if she's 200. This is very much like Josie, anything less than a 0.4u doesn't really work and sometimes the 0.4 really works. I believe, like Carl, this is something internal and my vote is the P, P action always seems to be much more pronounced under 200. Since the P can also correct low BG and cause a liver dump, I don't worry as much unless we're talking about a huge dose. Snowflake has proven she can handle low numbers pretty well, your SS is amazing because you were able to hold her so low for so long...most cats would be bouncy as hell from going as low as she got. Also, 0.4u going into a 330 vs. a 204 is much different, I actually think you did better with the 0.65u on higher numbers like you were doing before. If this holds, give her a good dose next cycle and see if you can knock those symptoms back down, glucose is eliminated through the kidneys after about 250 which is why you're seeing the drinking/urine increasing, nip that in the bud as soon as you can.