If you use a 500mg, you would just give less drops. Sam's current tincture is 250mg CBD, and 5mg THC. There is still debate about the safety of THC for cats (it's a big no-no for dogs), but a lot of folks in the pancreatitis group use it for the better pain management it gives, and so far so good as far as cat safety. However, since Little isn't dealing with pain, I think straight CBD would be just fine.
Are you both feeling better now? Are the storms over?
So if you're starting with a 500mg, I think I'd probably give one drop, and work your way up from there. The range of what seems to help cats is pretty broad, so you'll just have to try it and observe. In general people add a drop at a time until they hit a dose that makes them sleepy or relaxed (make sure to give it an hour in between so there is time to hit the system - absorbing through the digestive tract can be slow). Then back off one drop from that point for regular dosing, or go to that point when there is something acute (like a thunderstorm).
There are a couple of ways to administer. If little will let you, the best for absorption is to put the drop in the cheek pouch and let it absorb from there. She has to cooperate though, because you don't want to accidentally squirt in too much. No way Sam will let me do that, so I put a drop on a freeze dried treat, and let him eat them up. That makes for less predictable impact though since it doesn't absorb as well or as quickly. Still works, just takes a little more patience and monitoring.