Question on Smokey dose

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Olive & Paula

Member Since 2015
On his current dose of 1.75u it has bought him down to a green and then of course the bounce.

So does that mean we keep this dose and eventually it will level off and start to keep him in normal numbers longer? And it's okay that we are on this dose for a long period of time? He will bounce each time it drops and that is normal until it levels out. Guess I'm worried about not knowing if or when maybe it should be increased.

Please chime in.
 
So does that mean we keep this dose and eventually it will level off and start to keep him in normal numbers longer?
Sometimes kitties will level off after an extended period of time on a specific dose, but not usually. Generally speaking, when using Lantus, one would attempt to lower the entire range by increasing the dose.
And it's okay that we are on this dose for a long period of time? He will bounce each time it drops and that is normal until it levels out. Guess I'm worried about not knowing if or when maybe it should be increased.
It depends, what's your goal?
  • If status quo is the goal, keep on keepin' on.
  • If lowering the entire range is the goal, you'll have to increase the dose.
Depending on the cat, holding a dose for 3 - 7 days is plenty of time to see what the dose can do.
Hope this helps...
 
@Jill & Alex (GA), Paula was giving Smokey a higher dose and he went under 60 on her AT meter three times so she lowered it by 0.25. But now Smokey keeps going high. He had a green the other day and then... Boing!! So if she sticks with this dose, will his liver eventually get used to it?
 
@Jill & Alex (GA), Paula was giving Smokey a higher dose and he went under 60 on her AT meter three times so she lowered it by 0.25. But now Smokey keeps going high. He had a green the other day and then... Boing!! So if she sticks with this dose, will his liver eventually get used to it?
It's possible, but not probable. Smokey's body isn't going to "get used to" seeing green numbers when green is seen only occasionally... so he won't stop bouncing. It becomes a vicious circle. Something needs to change to break the pattern. He needs to "see green" more often so his body will stop reacting by bouncing. That usually takes more insulin, but how do you do that without causing hypoglycemia?

Probably the most successful technique I've seen/used is manipulating the curve with food. The method allows one to get more insulin into the cat and at the same time it helps prevent kitty from bottoming out. Those who work outside the home use timed feeders. Here's some basic info: Using food to manipulate the curve. Help with this can be found in the insulin support groups.
 
I'm stuck here. I shot low 12/25 but he didn't stay low. How would I have kept that run going? I read the link above. I have an auto feeder. He gets fed 5-6 times a day. He was getting 2 oz at shot time but not eating it all so I reduced the amount. He gets 1.5 oz @ +3 but was leaving some of it. So reduced to 1 oz. Lately he hungry at +7 or 8. But I only give him 1 oz so he will eat for the PS. Now we are 6 cycles after his good day. Which occurred on its own. How would I maintain the run? Should I have given him a fat dose on 12/26?
 
Sometimes kitties will level off after an extended period of time on a specific dose, but not usually. Generally speaking, when using Lantus, one would attempt to lower the entire range by increasing the dose.

It depends, what's your goal?
  • If status quo is the goal, keep on keepin' on.
  • If lowering the entire range is the goal, you'll have to increase the dose.
Depending on the cat, holding a dose for 3 - 7 days is plenty of time to see what the dose can do.
Hope this helps...

He's been on this dose 11 days. He hit the blues a few times and a green. But he bounces in between. He had a good run Christmas day. How do I get that back and keep it that way?
 
@Jill & Alex (GA), Paula was giving Smokey a higher dose and he went under 60 on her AT meter three times so she lowered it by 0.25. But now Smokey keeps going high. He had a green the other day and then... Boing!! So if she sticks with this dose, will his liver eventually get used to it?

Thank you, your wording is better. It doesn't look like there is an easy answer. I don't know what to do anymore.
 
Hi Woods! I haven't been on for awhile and I'm sorry to see Smokey is still having such a hard time. I took a bit of a drastic step with Dominick to deal with his crazy bounces. It worked, and he looks to be on the verge of going OTJ now, but it's risky and you may not want to try it. I only did it because I was beginning to consider euthanasia - it was so obvious that Dominick felt rotten when he was high, and he was high most of the time.

Starting Nov 20th, when he bounced high I gave him a bit of Novolin R to bring him down, while I continued to dose him with Lantus as uaual. That kind of short-circuited the bounces. A few weeks of that was enough to get his liver used to the lower numbers and to allow him to begin to heal. Check out his spreadsheet, the times I gave him R is in the comments. He went quite low a few times (remember I use the Relion when you see those numbers), but not from the R, those lows happened when the R was out of his system. They happened because he was getting better and needing less of the Lantus.

It's looking like this cat may see a fourth remission after all.

Spiderlilly
 
Paula, maybe going to a fat 1.75 or a skinny 2 would give Smokey a little more insulin without him going hypo. Or you might get some medium carb food if you don't have some, then go back up to the dose of 2 units and as Jill said, you could steer him with food to keep him from going hypo.
 
I'm stuck here. I shot low 12/25 but he didn't stay low. How would I have kept that run going?
You couldn't. His PMPS number was actually his nadir from the previous cycle.
I have an auto feeder. He gets fed 5-6 times a day. He was getting 2 oz at shot time but not eating it all so I reduced the amount. He gets 1.5 oz @ +3 but was leaving some of it. So reduced to 1 oz. Lately he hungry at +7 or 8. But I only give him 1 oz so he will eat for the PS.
If you're interested in learning to how to manipulate the curve with food you'll want to start as stated in the link I posted (for Lantus), "When using food to manipulate the curve, I generally recommend starting with dividing up the normal amount of food your kitty should be eating into 8 mini-meals to be fed at preshot, +1, +2, and +3 of each cycle. However, that recommendation is strictly a starting point. A plan customized for YOUR cat is YOUR goal. Frequent testing and learning how YOUR cat responds not only to food, but to the insulin itself will help you tweak the plan."

It's work and chances are you won't see immediate results. It's a process both on the learning end as well as for getting results.

You'll also want to learn/know Smokey's response to insulin:
  • Onset - the length of time before insulin reaches the bloodstream & begins lowering blood glucose
  • Peak/Nadir - the lowest point in the cycle
  • Duration - the length of time insulin continues to lower blood glucose
We've also found that feeding after nadir will often slow down or even stop the action of the insulin. If Smokey has to eat after nadir, try to limit it to low carb snacks if it doesn't stress him out too much.

Long explanation short: The goal is to prop up the cycle by strategically timed mini-meals. Initially the cycles will run a bit higher, but that's what enables you to give a higher dose of insulin without the fear of kitty bottoming out.
Make sense?

ETA: Experienced & seasoned members offering advice in the Lantus and Levemir ISG should be very familiar with using food to manipulate the curve.

How would I maintain the run? Should I have given him a fat dose on 12/26?
Generally speaking, you'll want to dose consistently, so no, you wouldn't have wanted to offer a "fat" dose on the 26th.

Honestly, if I were in your shoes I would bite the bullet and follow the TR Protocol to the letter. Smokey is not as "different" as I've heard you say. With as much as you test I think he would definitely benefit from an aggressive approach. Just my opinion.


Starting Nov 20th, when he bounced high I gave him a bit of Novolin R to bring him down, while I continued to dose him with Lantus as uaual. That kind of short-circuited the bounces. A few weeks of that was enough to get his liver used to the lower numbers and to allow him to begin to heal. Check out his spreadsheet, the times I gave him R is in the comments. He went quite low a few times (remember I use the Relion when you see those numbers), but not from the R, those lows happened when the R was out of his system. They happened because he was getting better and needing less of the Lantus.
Using R at the beginning of a bounce is a good option for some cats. However, in this case, the increased risk may not even be necessary if Paula follows a more aggressive treatment plan. The verdict is still out on that one.
 
Hi Woods! I haven't been on for awhile and I'm sorry to see Smokey is still having such a hard time. I took a bit of a drastic step with Dominick to deal with his crazy bounces. It worked, and he looks to be on the verge of going OTJ now, but it's risky and you may not want to try it. I only did it because I was beginning to consider euthanasia - it was so obvious that Dominick felt rotten when he was high, and he was high most of the time.

Starting Nov 20th, when he bounced high I gave him a bit of Novolin R to bring him down, while I continued to dose him with Lantus as uaual. That kind of short-circuited the bounces. A few weeks of that was enough to get his liver used to the lower numbers and to allow him to begin to heal. Check out his spreadsheet, the times I gave him R is in the comments. He went quite low a few times (remember I use the Relion when you see those numbers), but not from the R, those lows happened when the R was out of his system. They happened because he was getting better and needing less of the Lantus.

It's looking like this cat may see a fourth remission after all.

Spiderlilly

@Spiderlily your ss says denied access. I will talk it over with vet. His appointment was rescheduled for tomorrow . Only thing it's with other doctor who isn't as familiar with him.
 
You couldn't. His PMPS number was actually his nadir from .

So if the nadir is his PS it doesn't mean your shooting low even though the number is low.

The last 3 weeks he seems to be falling more into the guidelines than he use to be.

What should I have done to keep the 12/25 run going so he wouldn't have bounced on 12/26? On 12/25 it was all him. His regular meals no extra boost of food. So this dose looks like it can do it. So how do I keep it
 
So if the nadir is his PS it doesn't mean your shooting low even though the number is low.
Shooting a full dose on an 85 was shooting low no mistake about it. In this case (hindsight is always the best sight), the 85 was at or very close to nadir because the numbers went nowhere but up. BUT because it's a low number one wants to get those +1s and +2s just in case kitty will drop lower before the new shot onsets. If kitty continues to drop after the shot and being a fed a meal, chances are duration has increased beyond 12 hours. This is where carryover (insulin effects lasting past the insulin's official duration) and overlap (the period of time when the effect of one insulin shot is diminishing and the next insulin shot is taking effect) come into play.
What should I have done to keep the 12/25 run going so he wouldn't have bounced on 12/26?
Nothing. Smokey's natural reaction (defense mechanism) sprung into action... as it should. You weren't going to stop it.
On 12/25 it was all him. His regular meals no extra boost of food. So this dose looks like it can do it. So how do I keep it
I think you probably could keep it if you're satisfied with what the dose is giving you. It already looks like he's headed downwards today.

Again, the question is: what is your goal?
  • If status quo is the goal, keep on keepin' on. It's working. He'll probably continue to see occasional greens.
  • If lowering the entire range is the goal in an effort to get him into normal numbers overall, you'll end up having to increase the dose. Learning how to use food to manipulate the curve is a tried and true technique used to safely and successfully meet that goal.
 
So I should increase back to 2U and use food to control it?
No. You'll want to start here as well as ask for help in the Lantus ISG:

"If you're interested in learning to how to manipulate the curve with food you'll want to start as stated in the link I posted (for Lantus), "When using food to manipulate the curve, I generally recommend starting with dividing up the normal amount of food your kitty should be eating into 8 mini-meals to be fed at preshot, +1, +2, and +3 of each cycle. However, that recommendation is strictly a starting point. A plan customized for YOUR cat is YOUR goal. Frequent testing and learning how YOUR cat responds not only to food, but to the insulin itself will help you tweak the plan."

It's work and chances are you won't see immediate results. It's a process both on the learning end as well as for getting results.

You'll also want to learn/know Smokey's response to insulin:

  • Onset - the length of time before insulin reaches the bloodstream & begins lowering blood glucose
  • Peak/Nadir - the lowest point in the cycle
  • Duration - the length of time insulin continues to lower blood glucose
We've also found that feeding after nadir will often slow down or even stop the action of the insulin. If Smokey has to eat after nadir, try to limit it to low carb snacks if it doesn't stress him out too much.

Long explanation short: The goal is to prop up the cycle by strategically timed mini-meals. Initially the cycles will run a bit higher, but that's what enables you to give a higher dose of insulin without the fear of kitty bottoming out."





 
I've been reading the TR. Still find it confusing. Do I fall I to the increase phase? Or maintain phase?
I think everyone agrees Smokey needs more insulin, but my understanding from reading your other thread is you'll be holding the dose while learning to manage the curve with food.

Paula, please post your questions and thoughts in your other thread so everything is kept together and everyone is dealing with the same information.
Thank you!
 
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