Hmmmm. .045 doesn't seem to be doing much but one unit looked like too much. Normally we'd say hold on to dose for 3 cycles but I'd like to see her numbers lower. Can you monitor if we up the dose a smidge? Do you want to? (Your gut is important in this process). If you think increase, maybe 0.6 and plan to get a test early and depending on how it looks, maybe a nadir test.