Vet articles on home testing
Marilyn, Cheri/Louis did a lot of work to put this all together. Maybe print it off and give to your "former" vet and enlighten her on the subject and maybe some cats will be saved.
CONVERT-A-VET : Professional studies/articles on home testing
Posted by: Cheri and Louis (IP Logged)
Date: August 28, 2007 10:59AM
For folks who want to convince their vets of the value of home testing (as I did myself), here is a list I have put together and called "Convert-a-Vet". It is natural that your vet would want to see information from PROFESSIONAL VETERINARY sources, and these studies and comments on home testing blood glucose and on the use of portable blood glucose meters fit that qualification. The majority are from peer reviewed literature.
At the end of this I made a place for web sites of vets who support home testing and I've just put Drs Hodgkins and Pierson. Let me know if there are more you can think of, or if there are any other professional sources that would be useful for this list.
I can make a nicer looking version and save as a PDF if people think it worthwhile.
HOME BLOOD GLUCOSE TESTING FOR DIABETIC PETS: INFORMATION FROM VETERINARIANS
Home BG testing may not yet be common at many veterinary practices, but, far from being a radical, untested idea, it is recommended by…
National veterinary organizations….Veterinary textbooks…University veterinary hospitals… AAFP… VIN…Veterinarians who have specialized in DM
The Canadian Veterinary Association
Official advice for the treatment of pet diabetes is to home test
Information on their website: [www.animalhealthcare.ca]
Quote: "Recently, a home blood glucose monitoring initiative was reported in the literature that provided a practical method for owners to check blood sugar at home by doing a small prick in the ear and using a low volume automated glucose meter. This is a big step forward in feline diabetes management because it is well known that while in hospital for monitoring, cats tend to not eat well and are stressed, both of which can interfere with blood sugar assessment. It is important to have a blood glucose curve done after insulin therapy is begun so that the veterinarian can check how quickly a particular cat processes the insulin type prescribed. Cats have a very wide spectrum of time that it takes to metabolize the insulin, and this test is very important for the safety of long-term insulin therapy."
DVM Newsmagazine, Sept. 01, 2001 “Blood Glucose Monitoring”, Diane Monsein Levitan, VMD, Dipl. ACVIM, [www.dvmnewsmagazine.com] “There is a trend developing in veterinary medicine: using a blood glucose meter designed for human diabetics as a simple, rapid, pain-free method of getting immediate and accurate blood sugars on diabetic pets. The advantages of such a technique are clear: the pet is in its natural home environment, thus diminishing the role of stress on blood glucose values. Samples can be obtained easily in dogs and cats using a device purchased in any pharmacy by performing a simple ear stick technique to obtain a blood sample. Repeated sampling is easily performed. The results are a true measure of blood glucose at the time of the test (Proceedings of the 19th ACVIM Forum, Abstract #100). The test is simple to do and owner compliance is likely. The day-to-day variations of blood sugar in pets can be taken into account and insulin dosages can be adjusted on a daily basis, if need be. These methods have been described and have improved quality of glucose regulation and accurate assessments of insulin requirements. (Reusch CE, Wess G, Casella M: Home monitoring of blood glucose concentration in the management of diabetes mellitus. Comp Cont Ed Pract Vet 2001;23:544-556.)
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Canine and Feline Endocrinology and Reproduction, Third Edition (2003)
Feldman, Edward, DVM, DACVIM, and Nelson, Richard, DVM, Dipl ACVIM, School of Veterinary Medicine, Univ. of California, Davis ISBN-13: 978-0-7216-9315-6
In its chapter on feline diabetes, this veterinary textbook includes information and illustrated instructions for home testing (pp. 565-566) and recommends the “Sugarcats” website as a resource for clients.
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University of Zürich vet hospital's use of home blood glucose monitoring since 1999
Dr. Claudia Reusch, DECVIM-CA ,Clinic for Small Animal Internal Medicine, University of Zürich, discusses how home monitoring of blood glucose has been integrated into their protocol for treatment of DM since 1999 in presentations to the World Small Animal Veterinary Association World Congresses in 2002: Experiences with Blood Glucose Home Monitoring by Owners of Diabetic Dogs and Cats [www.vin.com] and in 2006: Update on Feline Diabetes Mellitus World Small Animal Veterinary Association World Congress Proceedings, 2006 [www.vin.com] Quote: “...A variety of problems are associated with the determination of BGCs in hospitalised patients. The process is time consuming and relatively expensive and therefore, is not performed as frequently as required. Stress or lack of food intake can markedly influence BG concentration….Therefore, in-hospital BGCs can be difficult to interpret or may even be useless. During the last years, methods have been developed for obtaining capillary blood (mostly from the inner ear) by means of lancing devices manufactured for humans. Measurement of blood glucose concentration is performed using one of the many portable glucose meters (PGM). …. “Measurement of capillary blood glucose (home monitoring, HM) has been part of the routine protocol for long-term management for diabetic cats in our clinic since 1999… About 70% of our cat owners are willing and able to perform HM. Also long term compliance appears to be good. In a recent study 76% of the owners performing HM used the technique for more than one year for up to 4 years. HM did not appear to influence the frequency of re-evaluations in the hospital. Most owners did not change insulin dosages on their own, but called for advice. All cat owners believed that HM had raised their self-confidence with regard to their ability to manage the disease in their pets. ...In our study the percentage of well regulated cats was higher than in comparable studies not using HM. Therefore we assume that curves generated at home reflect the true metabolic situation better than those performed in the hospital.”
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PUB-MED ABSTRACTS
USE OF PORTABLE BLOOD GLUCOSE METERS
& HOME BLOOD GLUCOSE MONITORING OF CATS AND DOGS WITH DM
ABSTRACTS - PBGMs
J Am Vet Med Assoc. 2002 Aug 1;221(3):389-92.
Comparison of glucose concentrations in blood samples obtained with a marginal ear vein nick technique versus from a peripheral vein in healthy cats and cats with diabetes mellitus.
Thompson MD, Taylor SM, Adams VJ, Waldner CL, Feldman EC.
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
OBJECTIVE: To compare blood glucose (BG) concentrations measured with a portable blood glucose meter in blood samples obtained with a marginal ear vein (MEV) nick technique, from a peripheral venous catheter, and by direct venipuncture in healthy cats and cats with diabetes mellitus. ANIMALS: 1 0 healthy cats and 11 cats with diabetes mellitus. Procedure-On day 1, blood samples were collected every hour for 10 hours by the MEV nick technique and from a peripheral venous catheter. On day 2, blood samples were collected every hour for 10 hours by the MEV nick technique and by direct venipuncture of the medial saphenous vein. RESULTS: For all cats, mean BG concentration for samples collected by the MEV nick technique was not significantly different from mean concentration for samples obtained from the peripheral venous catheter. For healthy cats, mean BG concentration for samples collected by the MEV nick technique was not significantly different from mean concentration for samples obtained by direct venipuncture. For cats with diabetes mellitus, mean BG concentration for samples collected by the MEV nick technique was significantly different from mean concentration for samples obtained by direct venipuncture; however, for the range of concentrations examined, this difference was not clinically important. Conclusions and Clinical Relevance: Results suggest that for the range of concentrations examined, the MEV nick technique is a reasonable alternative to venous blood collection for serial measurement of BG concentrations in cats.
PMID: 12164536 [PubMed - indexed for MEDLINE]
J Small Anim Pract. 2000 Feb;41(2):60-6.
Capillary blood sampling from the ear of dogs and cats and use of portable meters to measure glucose concentration.
Wess G, Reusch C., Clinic for Small Animal Internal Medicine, University of Zurich, Switzerland.
Two new methods for collection of capillary blood from the ear of dogs and cats for the measurement of blood glucose concentration using portable blood glucose meters (PBGMs) are described. The first method uses a lancing device after pre-warming the ear, while the second employs a vacuum lancing device. Both methods generated blood drops of adequate size, although the latter method was faster and easier to perform. Accuracy of the two PBGMs was evaluated clinically and statistically. Although assessment of statistical accuracy revealed differences between the PBGMs and the reference method, all of the PBGM readings were within clinically acceptable ranges. Measurement of capillary blood glucose concentration is easy to perform, inexpensive and fast. It may be used by owners to determine blood glucose concentrations at home, and could serve as a new tool
for monitoring diabetic dogs and cats. PMID: 10701188 [PubMed - indexed for MEDLINE]
Am J Vet Res. 2000 Dec;61(12):1587-92.
Assessment of five portable blood glucose meters for use in cats.
Wess G, Reusch C., Clinic for Small Animal Internal Medicine, University CH-8057 Zurich, Switzerland.
OBJECTIVE: To evaluate the clinical and analytic accuracy of 5 portable blood glucose meters (PBGM) in cats, with emphasis on the detection of potential sources of error. ANIMALS: 200 cats. PROCEDURE: Venous blood glucose readings from 5 PBGM were compared with the results of a hexokinase reference method. Agreement among methods was determined by error grid analysis and statistical methods. RESULTS: A total of 2,975 PBGM readings and 513 reference values were analyzed. The accuracy of the PBGM varied in different glycemic ranges. The largest differences between PBGM readings and reference values were in the high glycemic range; 4 PBGM underestimated and 1 PBGM overestimated the reference values in most instances. In the low and reference glycemic ranges, the absolute differences between PBGM readings and reference values were small. Despite the analytic differences in accuracy, 4 PBGM had 100% and 1 PBGM had 98.7% of readings in the clinically acceptable values of the error grid analysis. Within- and between-day precisions were good for all PBGM. Significant differences were not detected between readings of EDTA and lithium-heparinized blood and fresh blood without anticoagulant. Compared with these blood types, 1 PBGM had significantly different readings with fluoride anticoagulated blood. In blood samples with a low Hct, all PBGM overestimated glucose concentrations. Sample volumes < 3 microl resulted in inaccurate measurements in 3 PBGM. CONCLUSIONS AND CLINICAL RELEVANCE: Performance varied among the 5 PBGM analyzed; however, all PBGM were deemed acceptable for clinical use in cats.
PMID: 11131603 [PubMed - indexed for MEDLINE]
Clin Tech Small Anim Pract. 2002 May;17(2):70-2.
Portable blood glucose meters as a means of monitoring blood glucose concentrations in dogs and cats with diabetes mellitus.
Stein JE, Greco DS.Veterinary Teaching Hospital, Colorado State University, 300 West Drake Road,Fort Collins, CO 80523, USA.
The use of portable blood glucose meters (PBGM) has become common in veterinary medicine as a rapid means of monitoring animals' blood glucose in a variety of medical conditions. These hand-held monitors allow for diagnostic and therapeutic decisions to be made quickly and relatively inexpensively using only a small amount of blood. Both in conditions resulting in hyperglycemia, such as diabetes mellitus, and in those resulting in hypoglycemia, such as sepsis or the presence of an insulinoma, veterinarians have come to rely on PBGM to provide critical information on the status of their animal patients. In particular, PBGM are frequently used to measure individual blood glucose values in an animal over a period to create a blood glucose curve when evaluating the effectiveness of insulin therapy in diabetic dogs and cats. PMID: 12219719 [PubMed - indexed for MEDLINE]
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ABSTRACTS - HOME MONITORING OF BLOOD GLUCOSE
J Feline Med Surg. 2006 Apr;8(2):119-27. Epub 2005 Dec 1.
Home monitoring of the diabetic cat.
Reusch CE, Kley S, Casella M., Clinic for Small Animal Internal Medicine, Vetsuisse-Faculty University of Zurich, Switzerland.
creusch@vetclinics.unizh.ch
Many owners are able and willing to perform home monitoring of blood glucose concentrations in diabetic cats. Once owners are familiar with the technique, they appreciate its advantages and show long-term compliance. The success of home monitoring hinges greatly on careful preparation and instruction of the owner. Owners must have ready access to veterinary support if needed. Initially, most owners call for advice, and several of them need repeated explanation or demonstration of the procedure. The frequency of re-evaluations of the diabetic cats by veterinarians is not affected by home monitoring. One of its major advantages is that it enables frequent generation of blood glucose curves. In complicated cases, more than one curve can, therefore, be performed at home before a treatment decision is made. According to preliminary data cats managed with home monitoring may have better glycaemic control than those managed without. However, those results need to be confirmed in a large group of cats.
PMID: 16325445 [PubMed - indexed for MEDLINE]
Can Vet J. 2005 Aug;46(8):718-23.
Retrospective study of owners' perception on home monitoring of blood glucose in diabetic dogs and cats.
Van de Maele I, Rogier N, Daminet S.
Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, B-9820 Merelbeke, Belgium.
Isabelvandemaele@hotmail.com
Home monitoring of blood glucose (HMBG) concentrations has been recommended in the monitoring of human diabetics for 3 decades. During the last number of years, it also gained popularity in long-term follow-up of diabetic cats and dogs. The aim of this retrospective study was to evaluate the practical feasibility of and identify the major problems encountered with HMBG in diabetic pets. A standard questionnaire was filled in by owners of 9 diabetic pets monitored with HMBG. The need for more than 1 puncture to obtain a blood drop, the creation of a sufficient blood drop, the need for assistance in restraining the pet, and the resistance of the pet were the most frequently encountered problems during HMBG. The major obstacles for the owners to start with HMBG were also identified. In conclusion, HMBG is a practical and simple technique for most owners and, overall, owners were satisfied.
PMID: 16187716 [PubMed - indexed for MEDLINE]
Article online: [www.pubmedcentral.nih.gov]
J Feline Med Surg. 2005 Jun;7(3):163-71. Epub 2005 Jan 7.
Home-monitoring of blood glucose in cats with diabetes mellitus: evaluation over a 4-month period.
Casella M, Hassig M, Reusch CE., Clinic for Small Animal Internal Medicine, Vetsuisse-Faculty, University of Zurich
Home-monitoring of blood glucose concentrations has recently been introduced to owners. The objectives of this study were to investigate the feasibility of home-monitoring of blood glucose in diabetic cats by owners, the problems encountered and to compare glucose concentrations at home with those measured in the hospital. Twelve of 15 cat owners were able to generate glucose curves over the study period of 4 months. Most problems were related to restraining the cat, generating negative pressure with the lancing device and producing a blood drop. In the majority of cases, these problems could be resolved during the study. Blood glucose concentrations in the clinic tended to be lower than at home; some of the differences were significant. No association between tolerance of the procedure and blood glucose concentrations measured at home was found. We, therefore, assume that the lower glucose levels in the hospital were caused by lack of food intake. In 38% of cases, treatment based on hospital curves would have been different from that based on home curves. Home-monitoring appears to be a valuable tool in the management of cats with diabetes mellitus. One of its major advantages is that it enables frequent generation of blood glucose curves, which is of particular importance in cats that are difficult to regulate. PMID: 15922223 [PubMed - indexed for MEDLINE]
J Am Vet Med Assoc. 2004 Jul 15;225(2):261-6.
Evaluation of long-term home monitoring of blood glucose concentrations in cats with diabetes mellitus: 26 cases (1999-2002).
Kley S, Casella M, Reusch CE., Clinic for Small Animal Internal Medicine, Vetsuisse Faculty University of Zurich
OBJECTIVE: To evaluate owner compliance with longterm home monitoring of blood glucose concentrations in diabetic cats and assess the influence of home monitoring on the frequency of reevaluation of those cats at a veterinary hospital. DESIGN: Retrospective study. ANIMALS: 26 cats with diabetes mellitus. PROCEDURE: Medical records of diabetic cats for which home monitoring was undertaken were reviewed, and owners were contacted by telephone. Signalment, laboratory test results, insulin treatment regimen, details of home monitoring, clinical signs during treatment, frequency of follow-up examinations, and survival times were evaluated. RESULTS: Monitoring of cats commenced within 12 weeks (median, 3 weeks) after initial evaluation; 8 owners were unable to perform home monitoring, and 1 cat was euthanatized after 1 week. In 17 cats, duration of home monitoring was 4.8 to 46.0 months (median, 22.0 months); 6 cats died after 7.0 to 18.0 months (median, 13.0 months). In 11 cats, home monitoring was ongoing at completion of the study (12.0 to 46.0 months' duration). Fourteen owners completed blood glucose curves every 2 to 4 weeks. Cats managed with home monitoring received higher dosages of insulin, compared with cats that were not monitored. Four of 17 cats managed by home monitoring had transient resolution of diabetes mellitus for as long as 1 year. Home monitoring did not affect the frequency of reevaluation at the veterinary hospital. CONCLUSIONS AND CLINICAL RELEVANCE: Owner compliance with long-term home monitoring appeared to be satisfactory, and home monitoring did not affect the frequency of reevaluation of patients by veterinarians.PMID: 15323384 [PubMed - indexed for MEDLINE]
Clin Tech Small Anim Pract. 2002 May;17(2):86-95.
Home monitoring of the diabetic pet.
Mathes MA., Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
dogged@colostate.edu
Home monitoring of the diabetic pet is a challenging proposition for many pet owners. Diabetes, unlike many other diseases, requires that the client, not the veterinarian, treat the disease. It is crucial that veterinarians reinforce and educate clients that successful treatment of diabetes mellitus will depend solely on the client's actions throughout the course of the treatment. This article provides guidelines on educating clients in the home monitoring process.This commonsense approach covers elements of in-home monitoring, including general appearance, clinical signs, behavior changes, feeding schedules, and medication administration. Additionally, thorough explanation is provided for clients who wish to take a more active role in obtaining and monitoring blood and urine chemistry values. This information is provided to assist the veterinary technician and veterinarian in educating clients of their responsibility in treating this disease.
PMID: 12219722 [PubMed - indexed for MEDLINE]
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Other Articles
“Understanding feline diabetes mellitus: Pathogenesis and Management”, Rand, Jacquie and Marshall, Rhett, University of Queensland Center for Companion Animal Health, Australia, in Waltham Focus, Vol. 15 No.3. (2005). [www.uq.edu.au] “Blood glucose measurement at home in the cat’s normal environment has distinct advantages for the cat and provides similar data… Home blood glucose measurement removes much of the stress-induced hyperglycemia, as well as the problem of hospital inappetence…”
Susan Little, DVM, Dipl. ABVP, “Managing Chronic Diseases in Cats” DVM Newsmagazine online, 1 June 2005
[www.dvmnews.com]: Blood glucose curves are essential in managing feline diabetes, yet cats may be stressed during hospitalization, making it difficult to interpret results. One solution is to teach clients how to perform blood glucose curves at home using capillary blood sampling from the ear and a portable blood glucose meter. VeterinaryPartner.com offers an excellent client resource for home blood glucose monitoring, including a video demonstration.
Home blood glucose curves offer substantial benefits for veterinarians, patients, and owners. Evaluation of cats monitored with home blood glucose curves has shown that owners appreciate home blood glucose curves because they avoid the stress of hospitalization for their cats.10 In addition, cats are re-examined just as often, and owners aren't prone to changing insulin doses without consultation. In almost 40% of cases, home-based blood glucose curves suggested a different treatment plan than blood glucose curves performed at the hospital.11
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Client Information
American Association of Feline Practitioners and the Cornell Feline Health Center, Cornell University, College of Veterinary Medicine, Ithaca, New York, in a brochure for cat owners suggests the possibility of home blood glucose monitoring. “Some cat owners are willing and able to take on the task of measuring their cat's blood glucose levels at home rather than in a veterinary hospital-a potentially less expensive and more accurate monitoring method. Ask your veterinarian whether home glucose testing might be suitable for you and your cat. More information can be found online at
http://www.sugarcats.net/sites/harry/bgtest.htm.” Online version: [www.vet.cornell.edu]
Veterinary Information Network (VIN)’s VeterinaryPartner website has a page on Home Testing of Blood Glucose for Diabetic Cats including a video demonstration. [www.veterinarypartner.com] VeterinaryPartner’s page on DM includes a link to [www.felinediabetes.com], which recommends home BG testing as the best method of monitoring a diabetic cat.
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Websites of veterinarians that recommend home testing.
Dr. Elizabeth Hodgkins, DVM, is a feline nutrition expert and the creator of the canned formula of Purina DM. She has treated hundreds of cats with diabetes mellitus and has developed a protocol that has helped a majority of these cats to no longer need insulin injections. Home blood glucose testing is a crucial component of the protocol. Her website describes her successful protocol and the theories on which it is based.
[www.yourdiabeticcat.com]
Dr. Lisa Pierson, DVM, has an excellent website with very informative articles on feline nutrition and health. This article on feline diabetes recommends a low-carb wet diet and careful home monitoring of blood glucose, and includes instructions and photographs.
[www.catinfo.org]
Cheri and Louis
Louis dx'd Sept.2006 ~ Lantus (Glargine) Oct 2006-June 2007; Diet-controlled July 2007-June 2008 ; Hospitalized June 2008 - DKA, Pancreatitis, UTI, hepatopathy, etc. ~ Now on 2.25u Lantus BID. ~ We are using the German Tight Regulation Lantus Protocol ~~~ One tough Meezer! ~~~ Louis's Spreadsheet
Various info on Diabetes, Lantus, Home testing:
■Feline Diabetes Mellitus: Pathogenesis and Management (Rand,Marshall, U of Queensland)
■Dr. Rand's Lantus Protocol (University of Queensland)
■German TR protocol for Lantus or Levemir from
http://www.tillydiabetes.net
■Home Blood Glucose Testing for Diabetic Pets: Information from Veterinarians (longer version of our "CONVERT-A-VET post)
Feline Nutrition Info: ■Website of Dr. Lisa Pierson, DVM -
http://www.catinfo.org
■Dr. Elizabeth Hodgkins, DVM, Feline Diabetes and Obesity: The Preventable Epidemics
■www.catnutrition.org - Informative site from educated lay person
■Dr. Debra Zoran, PhD, DVM The Carnivore Connection to Nutrition in Cats JAVMA, 2002....READ & SHARE WITH YOUR VET!