Neutrophils appear slightly toxic

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wondercat

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Anyone have any idea on what is meant by the following on our diabetic kitty's lab work: Remarks: Slide reviewed microscopically. WBC count and differential may be inaccurant due to WBC clumping. Neutrophils appear slightly toxic.

When Monkster had her blood test, she was slightly dehydrated from vomiting (which is why I brought her to the vet). Her results looked really good with the exception of her T4; it was 5.8, whereas is was 1.9 only 3 months earlier. We have since doubled her Methimazole dosage.

Would her T4 have anything to do with why her Neutrophils appear slighty toxic?
 
What does your vet say? I had some bloodwork done last week on my civi Stuart and the vet was not concerned. She said a lot of the results recently have included the same remark.
 
Lab Tests Online has lots of information about lab tests, plus definitions of any underlined word

Here is the link for blood smear.

From the abstract cited above:
Toxic neutrophils were associated with "higher prevalence of fever, icterus, vomiting, diarrhea, depression, dehydration, weakness, and cachexia," {weight loss} "as well as leukocytosis, neutrophilia, left shift, neutropenia, anemia, hypokalemia, and hypocalcemia." {other blood and chemical abnormalities}

"The prevalence of shock, sepsis, panleukopenia, peritonitis, pneumonia, and upper respiratory tract diseases was significantly higher among these cats, as were infectious (viral and bacterial) and metabolic disorders." {more likely to be sick with severe illness}

A quick paraphrase of the abstract cited above: If you see toxic neutrophils, the cat is probably ill, and it could be serious, but more assessment should be done to clarify what is going on.
 
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