L-Lysine is helpful for kitties with feline herpes which leads them to be more prone to upper respiratory infections. During a URI flare up I give 250mg twice a day. Some people will give 250mg daily as a preventative measure, although I am not sure whether this is helpful or not. I purchase the capsules (500mg) and split the contents and apply directly on the food. You can also buy the NOW brand lysine in bulk powder and measure out according to the dosing instructions. Just make sure that whichever brand you buy it has no fillers.
Supplements:
- L-Lysine* – 500mg for up to a week, then 250mg maintenance dose
*Unfortunately, cats that recover from the herpes and calici virus tend to become carriers and "shed" the virus throughout their life particularly in times of stress. If your cat has a flare-up of symptoms, 500mg of the amino acid L-Lysine works very effectively. Cats need the amino acid arginine, and since lysine and arginine compete with each other, do not exceed a maintenance dose of 250mg on a long-term basis. If your cat only has occasional symptoms, give L-Lysine only when needed in the most conservative dose – 250mg and increase to 500mg only for short periods of time. A very large % of cats have been exposed to the herpes virus, and on my list over the years we've found lysine helps all cats with URI symptoms even if not officially diagnosed with herpe
http://www.holisticat.com/en/acute-conditions/37-uri.html
ETA This should only be a first line treatment for URI. If the kitty does not improve then a visit to the vet is in order.