I opened your spreadsheet.
I would encourage you to post this question on the Health forum, because most of us in the Lantus forum are not very familiar with N. I think you need a different set of eyes. Here is the link to Health:
viewforum.php?f=3 and a link to the Vetsulin/N group:
viewforum.php?f=19 Your dose seems very high to me, and it seems like the dose was not reached in a safe way. Most start on 1 unit of N and hold that for a little while to see what happens before increasing. Meadow had a couple of 100's on 2 units, then when you increased from there everything got worse. I would try to get some numbers earlier in the cycle, like after 3 or 4 hours instead of 6. That's when you're likely to catch any lower numbers on N. Then post your numbers on Health or in the Vetsulin/N group for help in interpreting them.
Also here is the Humulin N Primer:
viewtopic.php?f=19&t=303&view=unread#unread
The curves in this spreadsheet are from Lantus, is that right? I tried to copy the numbers here for you, I have no idea what the format will look like once I hit "submit" so apologies if it is hard to read.
Meadow's Lantus Spreadsheet
Date AM BG Units 6th Hour PM BG Units 6th Hour Remarks
3/18/2010 371 At Vet office BG >600. Vet gave 1st dose of Lantus - I tested 6 hours later.
3/19/2010 314 2 169 2 303 Confusion on testing at night. Vet said to test only on 6th hr (?)
3/20/2010 387 2 405 2
3/21/2010 191 2 343 2 343
3/22/2010 294 2
3/27/2010 403 2 Go to remarks
Curve every 2 hrs for 12 hrs: 403, 449, 408, 392, 380, 344, 401
4/3/2010 452 3 See remarks Insulin increased / curve: 452, 500+, 500+, 500+, 500+, 463, 500+, 500+
4/4/2010 500+ 4 500+
4/5/2010 491 4 476 2
4/10/2010 418 4 See remarks Insulin increased / curve: 418, 500+, 500+, 500+, 500+, 500+, 454
4/18/2010 461 5 See remarks Insulin increased / curve: 461, 500+, 500+, 500+, 500+, 500+, 500+
4/19/2010 476 5 490 5