? High dose kitties and increases

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Elizabeth B

Member Since 2017
Hamilton has become a high dose kitty (our vet suspects acromegaly, though it isn’t confirmed) and I’m a bit fuzzy on how much we should be increasing. I know we are racing insulin resistance and half dose increases aren’t really impacting his nadirs (we suspect the couple low readings were due to not enough of a sample as he was dehydrated), but I certainly don’t want to make a mistake with dosing. Does anyone know when you start increasing the dose by more than 0.25-0.5?
 
You can think of the increase as a percentage of the total dose. You are doing 0.5 unit increases now, which is good when you get to a total 5 unit dose. That's a 10% increase. However, if you start seeing greens, you might sneak the dose up by .25 units. Whereas a 0.25 unit increase would be 10% for - 2.5 total dose.

Hamilton's numbers are definitely starting to look better. It's possible those blues were accurate. But we do suggest people get testing done for the high dose conditions, acromegaly (IGF-1 test) and insulin auto antibodies (IAA), when the total dose gets to six units on an all wet food low carb diet.
 
Hamilton’s symptoms of acromegaly are insulin resistance, jaw changes, heart murmur, and CKD. My vet feels confident that it’s Acro and feels our treatment plan would be the same whether it’s confirmed or not, which is to control through diet and meds. He’s not a good candidate for any anesthetic procedures because of his heart. I just don’t know enough to agree or disagree and have had a hard time sorting through the information as he seems to have every complication possible. I’ve been through the Acro stickies. Is there more/better info out there?
 
My Neko had both a heart murmur and stage 2 CKD when she had her second SRT (stereostatic radiation therapy) to treat her acromegaly tumour. I had it done at Colorado State University. They had me get an echocardiogram and recent blood work before I went there. Do you know what is the issue with Hamilton's heart? Later on Neko got a 2nd degree heart block and could not undergo anesthesia.

There are other options - if you know for sure that Hamilton has acromegaly. Some of the people here have had success with a drug called Cabergoline. Here is a post with more information about it.

The acro sticky notes need a little updating. Sorry, it's on my "to-do" list. :oops: And here is another post with some collections of articles on acromegaly. Again, my bad, I have to put some of the medical solutions (pasireotide and cabergoline) articles on there. Unless you are really rich, pasireotide is probably not one you would consider. And if you read Yum's post from yesterday, MJW just got the acro diagnosis and her post has a lot of information in it on treatment options.

In the mean time, gettting to a dose where he spends most of his time under renal threshold is a good goal. Other things you can do to help him are to spread his meals out a little. Neko got several small meals in the first half of the cycle. It helped curb her voracious appetite. At some point, if you find Lantus stings Hamilton (which it's acid base can do at higher doses), you may fine a switch to Levemir insulin helps.

And lastly, what meds/supplements is Hamilton on? It can help to put when you stop or start meds into the Remarks section of the SS, to see if there is any corresponding result in numbers. And speaking of numbers, for the Labs page of the SS, we need to see the reference ranges for the lab you are going to. They do vary by lab, and the measures are different in the US than the rest of the world.
 
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