Hi ... My buddy Scottie and I .are new to diabetes. while I've read a great deal, I'm having problems with reactions to the initial PZI insulin shots. Scottie is a 10-year old male neutered tabby. He was 16 lbs. pre -diabetic diagnosis and has dropped 4 lbs in the past 2 months. When diagnosed 2 weeks ago, his blood sugar was > 400. No ketones; no other apparent problems. Within days of his diagnosis, I switched him to a low-carb high protein canned diet which he loves. The Vet started him on 1 unit of PZI twice a day. After the third shot, he refused to eat (VERY unlike him). Vet said to discontinue insulin until he started to eat normally again, get a home blood test kit, restart the insulin a\t 1/2 unit once a day; and then begin doing a glucose curve testing on the third day. Sunday I tested his blood for the first time (quite tricky to do!) and it was > 400. I gave him his insulin. He ate and acted normally pretty much all day. Today, I had to tear the house upside down for him after feeding him (he only ate a little) so as to find him to give him his shot. He was hiding under my clothes in my closet. I gave him ths shot and he never came out of the closet for the rest of the day. I checked on him a couple of times and he seemed OK ... just lethargic and depressed, but not disoriented. However, pretty strange behavior for this particular cat. About 7 PM tonight, I carried him downstairs, did a blood check (364) and offered him some food, which he readily ate. Later this evening, my husband said he was hanging out on his chest while they watched TV (I had to go out of town for 24 hours for work). He's supposed to get another insulin shot tomorrow AM but I am very hesitant to give it to him colnsidering his behavior today. Is this type of reaction "normal"? Is he just getting used to the insulin? Please help ... I don't feel like I know what I am doing, yet Scottie's life could depend on it. Thanks - Jeanne