Hi Sheri and Dante! Welcome to LL! I don't post here as often as I used to, but I try to stop in occasionally if I think I have something to add.
My suggestion before you make any more changes is to spend the next couple of days getting as much data as you can. Then you will be able to make informed decisions. Slowing down for a few days won't hurt anything and it will give you a much better idea of how to proceed. The tresaderm probably isn't helping his numbers, but if he needs it he needs it. Just expect that he might need to come down in dose once he goes off it, and you might need to adjust quickly. Follow the numbers.
I've been studying your spreadsheet and I have a few thoughts.
One, I actually don't think it's bad that you reduced the dose last week. The increases from 1.75 to 2.0 to 2.25 to 2.5 were all done pretty quickly and without enough data to support the increases, so you're right, he *might* have been over dose then. I probably would have only reduced back to the 1.75 (because you did have data to support that dose), but that's ok. By going down to a lower dose and working up, at least when/if he gets back to 2.5u you will know that it is a good dose.
But..... you really, really, really have to get spot checks before doing any more dose increases. You need to get some PM spot checks too. I don't mean you have to test around the clock, but at least one spot check every night (most of us get a before bed test) and then whenever you are home during the day is needed. There will be times when you'll need to test more than that (especially when he starts changing), but plan on that to start. Dante's spreadsheet shows that he actually CAN drop from this dose - he came down from 400s to 200s on 1.5u on 10/10. Might he be coming down farther than that sometimes and bouncing? He might, and you don't want to increase the dose any more until you're sure. The TR protocol is based on making changes because you KNOW the current dose isn't working. Trying to guess makes it unsafe.
About using R, most of the time we find that Lev kitties using TR do not need R, but it is another tool in the tool box and it's doable if Dante needs it, with some caveats. ;-) Again, the first step is to get data. First you need to understand his Lev cycle (onset, nadir, duration, what makes him bounce and how long do his bounces last, how quickly does he come down from his bounces, how carb sensitive is he so you'll know how to control the cycles if you need to, things like that). Then you figure out the same things about his R cycle. Then you lay the R cycle on top of the Lev cycle to figure out the best times and circumstances to use R. Adding R to Lev will require more testing, but it's doable. Also know that if you add R now, you will probably find that everything you learn will change once he gets off the Tresaderm and the infection is gone. It is likely that those things are causing some insulin resistance right now.
I hope that helps!