Regarding TR et an SLGS, here's some "newbie explanation", because it was hard for me to wrap my head around it last week, and I think I've finally understood. Here's my story.
Quintus and I started out on Lantus with the idea that we would rather easily find "the right dose" to keep him in the yellows and purples. Look at the preshot value, get a nadir here and there, adjust. Unfortunately (or fortunately) that's not how Lantus works. Lantus creates a kind of "stock" (the depot) of insulin under the skin. That means that when you give your cat a shot, most of the insulin is simply "stocked for later" and diffuses slowly (mainly over 12 hours but still significantly over the next 2-3 days or so). That means that when you do a dose change you can't really see how it's going to affect the BG until a few days after.
Also, what seems to happen is that after a dose change, particularly an increase, BG tends to go a bit all over the place ("New Dose Wonkiness" and "bouncing"). I'm not 100% satisfied I've understood the mechanisms for those, but after looking at lots of spreadsheets, it does indeed seem that this is commonly observed.
So, when you change a dose with Lantus, you should keep it going at least three days to see "what it's worth". And if it is a big dose change, it might throw things off more, because the depot is then way out of line with the dose you're injecting. Lowering or raising the dose by small increments gives you less wonkiness and yoyo effect.
So, TR and SLGS in all this?
If your goal is to get your cat "
tightly regulated" (mainly greens and low blues) or in remission, we have two "recipes" to get there. One is
TR, and it is a protocol that has been scientifically validated, and the other is
SLGS, and it is a method that people here have been using with success, but might not have the degree of scientific cred that TR has. You'll probably have to read the stickies more than once to get a good picture of what they imply and how they differ, but what they have in common is that they offer "rules" for when to change a dose, how much to change it, and how to monitor. Some differences I've noted: TR requires the cat to be on low-carb wet food, whereas SLGS does not. TR allows you to adjust the dose every three days, whereas SLGS only allows for that once a week.
Another thing I hadn't understood initially is that this "tight regulation" both TR and SLGS aim for is beyond what most medical professionals would try to get to. Mainly, I think, because TR and SLGS require high commitment from pet owners and from a certain point of view it's better to have a not-so-well-regulated animal than having the owner put it down because they're daunted by the requirements of caring for it. And also because new science/knowledge in some specialised areas takes time to seep into the mainstream. People here routinely shoot on numbers that vets would not be comfortable recommending, because it's risky to do if you don't have a pile of prior knowledge to help you guess how your cat is going to react, aren't monitoring, and don't know how to
deal with low numbers.
I initially got a bit frustrated with people telling me to choose one of SLGS or TR, because I wasn't doing either of them (and still am not), I was trying to do what seemed best to me between my discussions with my vet and what I was learning on the forum. Also, I'm not really aiming for tight regulation with Quintus right now. That will probably change, but now, I just want to get through the next few weeks with enough hours of the day under the 350s, and without the huge spikes in the blacks and the reds. And in all honestly, though I am a committed and devoted cat owner, the TR protocol scares me, because I am away so much. (If this had happened six months ago when I was still self-employed and working from my office two floors below home, I'd probably have dived in.) I didn't see how I could do SLGS as I definitely wasn't "starting low" and didn't want to "go slow". Last night I had I fruitful exchange with
@Kris & Teasel which helped me
figure out how to create a "bridge" from where I was to getting on board with SLGS (click on the link and read from there).
Wow, I wasn't intending to write so much. I hope this testimonial allows you to see a little clearer regarding the "TR or SLGS?" question.