AliMA
How was the Cushing's (hyperadrenocorticism) diagnosed. It is very difficult to determine that it is Cushing's without some specific test and an ultrasound. Cushing's has been considered rare in kitties, but that may be because of lack of having the testings done and under-reporting/under-diagnosing. Since many of the symptoms can be linked to other conditions, often Cushing's is not thought of or investigated.
These are some of the common symptoms of Cushing's
- Excessive drinking (polydipsia) and excessive urination (polyuria)
- Increased appetite
- Enlargement of the abdomen (a pot-bellied appearance)
- Lethargy
- Muscle wasting and weakness
- Poor coat condition
- Hair loss
- Curling of the ear tips
- Thin and fragile skin
In my kitty's case he has never lost weight even with the diabetes, in fact he has gained weight. Some Cushing's kitties will lose weight. Keep in mind that these symptoms can be linked to other conditions as well, so just because a kitty shows some or all is not a guarantee that they have Cushing's.
Cushing's can be either iatrogenic...which is caused by long term use of steroids. or tumour based...either pituitary or adrenal. The iatrogenic form is extremely rare in kitties as they can tolerate steroids much better than a person or a dog.
The PDH (pituitary dependant hyperadrenocorticism) is the more common type and is caused by a tumour on the pituitary gland. ADH (adrenal dependant hyperadrenocorticism) is caused by a tumour on the adrenal gland. The long and short of Cushing's is it causes cortisol to be released constantly, without the normal controls the body has to turn if off and on. Cortisol is a natural steroid type hormone that the body produces, but with both PDH AND ADH the body is not able to turn "off" the cortisol production.
These two links give a basic easy to follow explanation of Cushing's and are good as an introduction:
http://icatcare.org/advice/cat-health/hyperadrenocorticism-cushings-disease
http://www.petwave.com/Cats/Health/Cushings/Treatment.aspx
The least invasive, least expensive and easiest test to do initially is the UCCR (urine cortisol creatinine ratio) test, which involves collecting a urine sample AT HOME. so there is no stress involved. This sample would be taken to your vet and they would ship it to IDEXX or another outside lab that performs the test. If the results are negative, then no further testing is needed. If the results are positive or border line, then further testing is indicated. This article expalins the UCCR test:
http://veterinarymedicine.dvm360.co...eatinine-ratio-most-useful-normal-test-around
It is written about the test for use with dogs, but at this time there is no specific feline UCCR test, so this is the same one that would be used with kitties.
I have rather rambled on at this point, and could continue to do so for many, many more paragraphs, but at this point the important question is whether your kitty does in fact have Cushing's and what method was used to diagnose it.
Hope this has been helpful to start with.