Chronic Inflammation (UPDATE: Pancreatitis) & Diabetes

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RenaRF

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Hey everyone. This regards my 15 year old Clide. Since switching him exclusively to Merrick Cowboy Cookout wet and eliminating dry food from his diet, he's gone from BG pre-switch in the low 300s to a BG that now - even at the vet's - hovers between 115-130. Awesome.

At any rate, Clide DOES have other issues. He had his remaining teeth extracted in early January to try to help his stomatitis. It HAS helped, but there are still raw-ish spots in his mouth from time to time.

Outside of that, after the tooth extractions and diet change, the past 2+ months have been GREAT. His dandruff has almost completely cleared up, his coat is shiny, and his energy level is really excellent (he chases toys, my female kitty Bella, balls, you name it). Everything was really good until late yesterday.

Clide left us two little out-of-litterbox instances of diarrhea. One of them had enough blood in it (more than a speck) to cause me concern. The diarrhea persisted through this morning with a little more visible blood. Clide was otherwise eating fine (he LOVES food) and behaving normally. We had a vet appointment at 3pm today. We did:

- Bloodwork
- Fecal
- Xrays

We reviewed past bloodwork - there's a mild concern that there's a pattern of high-ish serum protein and high globulins which - the vet says - MAY indicate some underlying issue with chronic inflammation (we don't know yet). Today's bloodwork won't be back until tomorrow at the earliest. The xrays showed a whole lot more diarrhea and gas to come, so Clide is off food for tonight until tomorrow morning (NOT going to make him happy) to give his bowels a rest. There was nothing else remarkable on the xrays or that the vet observed on abdominal palpitation, but the caveat is, obviously, that there *could* be things that the xray wouldn't show. We have been sent home with Flagyl (metronidazole), 1/2 of a 250mg tablet 2x daily and proviable, a probiotic (both paste and tablet form).

So my question is this: IF Clide suffers from some kind of chronic inflammatory issue, what are my options? The normal treatment, obviously, would be prednisolone or prednisone. Is anyone else out there dealing with IBD-like issues AND feline diabetes? Any tips or advice?

Thanks,
Rena & Clide (and Rufus, Feats, Meatball & Bella)

UPDATE, 3/17/2012, 12:28pm EDT: Last night Clide was just "off". The giveaway that something was wrong was that he totally turned down food. NEVER. HAPPENS. He's a foodie. Eats and then begs for more. It was also obvious to me that he was highly uncomfortable. He went to the ER vet at about 10pm and is still there right now.

He had an ultrasound and internal medicine consult this morning. The specialist found that his spleen and liver look "coarse", but no masses or lumps or suspected cancer were found (WHEW). His pancreas is definitely inflamed, and they thought his kidneys looked like an older cat's kidneys (though his kidney values with serum bloodwork remain well within normal, so that's good). The thinking at this point, given that he came to me at age 14 with an unknown and pretty clearly medically neglected background, is that he had an acute pancreatitis episode.

I will be able to collect him later today. I spent time with him - they are giving him IV Flagyl and say they will likely add a secondary antibiotic to that mix, and they are hydrating him via IV (heart has a very slight murmur but is otherwise good and lungs are clear). He is also receiving Buprenex for the pain of the flare-up. We will review the bloodwork, urinalysis and fecal results when I get him at about 4pm. He was clearly happy to see me - active (they are obviously managing his pain), ate food for me, head butted etc. Turns into grumpy hissy growly Clide every time a tech checked in. :)

The supervising vet feels that the pancreatitis is caused by what may have been long-term untreated diabetes. Does anyone have experience with this? Any advice? I want to AVOID another incident in the future, obviously.

Clide at home last year:

Clidewithballs.jpg


Clide at the ER/specialty vet today (closed his eyes as I snapped - note his soft, pink, shaved and FAT belly from the ultrasound):

ClideatHope.jpg
 
Re: Chronic Inflammation (IBD?) & Feline Diabetes

RenaRF said:
Hey everyone. This regards my 15 year old Clide. Since switching him exclusively to Merrick Cowboy Cookout wet and eliminating dry food from his diet, he's gone from BG pre-switch in the low 300s to a BG that now - even at the vet's - hovers between 115-130. Awesome.

At any rate, Clide DOES have other issues. He had his remaining teeth extracted in early January to try to help his stomatitis. It HAS helped, but there are still raw-ish spots in his mouth from time to time.

Outside of that, after the tooth extractions and diet change, the past 2+ months have been GREAT. His dandruff has almost completely cleared up, his coat is shiny, and his energy level is really excellent (he chases toys, my female kitty Bella, balls, you name it). Everything was really good until late yesterday.

Clide left us two little out-of-litterbox instances of diarrhea. One of them had enough blood in it (more than a speck) to cause me concern. The diarrhea persisted through this morning with a little more visible blood. Clide was otherwise eating fine (he LOVES food) and behaving normally. We had a vet appointment at 3pm today. We did:

- Bloodwork
- Fecal
- Xrays

We reviewed past bloodwork - there's a mild concern that there's a pattern of high-ish serum protein and high globulins which - the vet says - MAY indicate some underlying issue with chronic inflammation (we don't know yet). Today's bloodwork won't be back until tomorrow at the earliest. The xrays showed a whole lot more diarrhea and gas to come, so Clide is off food for tonight until tomorrow morning (NOT going to make him happy) to give his bowels a rest. There was nothing else remarkable on the xrays or that the vet observed on abdominal palpitation, but the caveat is, obviously, that there *could* be things that the xray wouldn't show. We have been sent home with Flagyl (metronidazole), 1/2 of a 250mg tablet 2x daily and proviable, a probiotic (both paste and tablet form).

So my question is this: IF Clide suffers from some kind of chronic inflammatory issue, what are my options? The normal treatment, obviously, would be prednisolone or prednisone. Is anyone else out there dealing with IBD-like issues AND feline diabetes? Any tips or advice?

Thanks,
Rena & Clide (and Rufus, Feats, Meatball & Bella)

My only suggestion would be to possibly try a raw diet. A lot of people have reported that their kitties diarrhea went away after switching to raw as well as the raw helping with the IBD symptoms.

Also, Dr. Lisa has talked about Carrageenan as one ingredient in canned food that causes intestinal inflammation in human cells. Her thinking is that it probably does the same in cats and could be especially bad for IBD kitties. Check the labels on your canned foods and see if it is listed there.

You might find some other helpful suggestions in a recent thread further down the page here:

http://www.felinediabetes.com/FDMB/viewtopic.php?f=28&t=65826

Also you might consider a consult with Dr. Lisa to see what she thinks. You will need a copy of the bloodwork and anything else you can provide for her.

DrPierson@catinfo.org
 
Re: Chronic Inflammation (IBD?) & Feline Diabetes

My Boomer had IBD and he was put on pred which caused diabetes. We switched him to budesonide which is a steroid but it works differently, it's localized in the body or something...sorry...I never quite got that...but it worked and he was able to go OTJ after.

The other option is raw - Boomer wouldn't eat it, but I tried. You could try Nature's Variety which is a pre-made frozen raw in medalions and see if Clide will eat it. SInce he's a good eater maybe he will!
 
Re: Chronic Inflammation (IBD?) & Feline Diabetes

What you described is what both Simba and Gustav has:

- Gustav is the non-diabetic but has high plasma protein and immunoglobins values since 2008, but also have low white blood cells which he always have had - now that combination of Gustavs, is prevalent with leukemia, SLE, FIP and bone marrow plasma cell cancer multiple myeloma. In Gustav's case it isn't FIP, because as the vet said then they normally die, and since he got the high proteins and immunoglobins in 2008 at age 13 and is 17 now and still alive, we've ruled out FIP.


- Simba is the diabetic since 2006 when he was 10 and he is 16 now. End of 2010 he started to often have loose stool but in the litter box. That continued through 2011 and 2011 he also got Flagyl, which helped while he was taken it, but then he started to spit it out, and soon the loose stool came back. Then it has been loose stools sometimes, firm stool somedays and going from pooping once a day to pooping twice a day. By the end of 2011 though, he also got acute diarrehas, so acute he never made it into the litter box but instead had the diarreha on the bathroom floor just in front of the litter box. And then the blood in the diarreha came. I had Gustav's Prednisolone at home and tested to put Simba on that and he got one tablet a day for 13 days. For those days no diarrhea at all, and he was well for a month after the last tablet, but then this acute diarrhea with lots of blood in came back. So I put him back on Flagyl during 14 days, and he recently finished the last tablet. No diarrhea while on the Flagyl as well .... but now a week after the last tablet the loose stool are back. But since the Prednisolone and the Flagyl helped while taking them, I assume Simba also have IBD.
 
Thanks for everyone's replies. I've updated - while there may be some IBD-ish thing going on under the covers, a trip to the ER vet after Clide was obviously painful and REFUSED food (NEVER happens) has come up with the conclusion of an acute attack of pancreatitis. This is apparently common in diabetic cats? Or at least causally related?

Regarding food: I've discussed a raw diet with two vets and because of Clide's other issues (stomatitis, immune-related), they don't recommend it.

I checked the Cowboy Cookout ingredients - and yep, Carrageenan is there. I think I might want to find a good canned food that is:

1. Carrageenan free
2. Lower in phosphorus (While not a kidney kitty, the ultrasound DID show that his kidneys look like an older cat's kidneys)
3. Grain free
4. Very low carb

Any ideas?
 
I should also mention - They DID send out GI bloodwork, including the spec fPL to test for pancreatitis.

He had a full senior blood panel at the vet's yesterday as a well as a fecal - the ER vet will have those by the time I pick him up.
 
The only vet I've ever heard of who was in favor of a raw diet is Dr. Lisa. No vet of mine (and I have seen several in the last few years) will ever endorse it. I don't know if they aren't up on the latest stuff in feline nutrition or it they are right and it is dangerous. I've heard mostly positive about raw - the only negatives are the cats won't eat it and one case here on the board that the cat got sick after eating raw- but it can't be specifically tied to the food.
 
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