? Chlorambucil for lymphoma

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It's weird trying to figure out whether to try out the chlorambucil for a month or make arrangements for him after putting him to sleep. I found an online support group for anticipatory grief for those about to lose a pet. Also, one for people that have pets with cancer.
 
It's weird trying to figure out whether to try out the chlorambucil for a month or make arrangements for him after putting him to sleep. I found an online support group for anticipatory grief for those about to lose a pet. Also, one for people that have pets with cancer.
This is one of the really good things about the Internet - finding others who're going through what you are.
 
These on line support groups can be a good thing to join. I joined the Rainbow Bridge Pet Loss support group after Ms.Kitty passed and it was very helpful at the time. It really helped me to be able to process a lot of what I was feeling.
 
I saw that support group as well. I wish I could find a way for Smoky to feel better now. I hate the idea of taking him to the vet to be put to sleep since he will get stressed by the car ride and being away from home. It's extremely expensive to have that done at home.
 
I couldn't do the "pulse dosing" or once every two weeks in my area even if I wanted to. They won't do that where I live. It's only prescribed by 2 mg capsules given twice a week. Plus we have three cats and I wld have to lock Smoky in my bedroom for 2 days after giving a dose.
He would be locked up all the time with that type of dosing schedule. That's just not fair to him
 
(((Lisa)))
I'm so sorry you are having to make these decisions. I know how excruciating it is and wish I could help make it easier for you. Whatever you decide for your sweet boy will be the right decision at the right time. I don't have any knowledge of the meds you're talking about, so I can't offer anything there. Just thinking of you and Smoky.
 
You could always do your own type of dosing once you got the chlorambucil and try the every other week. They do make this in a pill form and also in chew treats from compounding pet pharmacies but it doesn't sound like your vet is willing to offer an alternative form of the med. Of course then you would still have the problem of separating him from the other cats, just not so frequently. I was in a really confused place dealing with this at one time but eventually it became pretty clear what I needed to do. It takes time to process all of it.
 
To do that I wld have to give him 2 capsules in one day of 2 mg each and then repeat that two weeks later. I don't know if that wld be safe or not since it is a powder inside a capsule. I think the every other week dosing is usually 4 mg every two weeks, isn't it? I don't know much about that.
 
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I can't remember what dose my kitty was on but I do remember that it was every other week and initially was a tablet. I later had it compounded into a chicken flavored liquid. It seems kind of odd that the clinic didn't offer any other form and dose. They must have their own protocol that is pretty much set and that they don't vary from.
 
My current vet still says 2 mg twice a week. I was thinking of giving him 4 mg once a week. She also said even with the chlorambucil he might only have three months to a year. I'm not sure I want to put him thru all of that just to keep him going for me.
 
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The vet gave me vitamin B12 to give to Smoky once a week. Here is a pic of a 1 mL syringe. It's a pretty big syringe and instructions are to give 0.25 ml. Does anyone know where that is on the syringe? Is it halfway mark between 0.2 and 0.3 mL on syringe?
 

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An endoscopy or surgical biopsy is the gold standard for diagnosing small cell lymphoma. But you have to do those before starting pred. My civie is on both prednisolone and Leukeran (chlorambucil) and has been over a year. The pred immediately stopped his vomiting. My girl Neko was on budesonide and Leukeran. She had heart issues which precluded pred, and it doesn't impact the blood sugar as much.

There are a couple of protocols for the chlorambucil. The pulsed dosing or dosing every two weeks is usually easier on them than the every other day method.

There is a online groups list for Feline small cell lymphoma that you might want to join.
My current vet insists there are guidelines she has to follow and the pulse dosing is not a part of that. She said that she can't prescribe every other week dosing schedule. I live in northeastern PA where they only allow for every other day dosing or twice a week dosing.
 
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Yes, 0.25 ml is halfway between 0.2 and 0.3
Thank you @Larry and Kitties
My vet called in a script to a compounding pharmacy for twice a week dosing, capsules are 2 mg each. Is it safe to give 4 mg once a week or better to keep to the 2 mg twice a week? My vet also tried to tell me it's not necessary to separate the cats if one is on Chlorambucil. I have had everyone on here tell me differently. I don't know what to think now.
 
I couldn't do the "pulse dosing" or once every two weeks in my area even if I wanted to. They won't do that where I live. It's only prescribed by 2 mg capsules given twice a week. Plus we have three cats and I wld have to lock Smoky in my bedroom for 2 days after giving a dose.
He would be locked up all the time with that type of dosing schedule. That's just not fair to him
I wonder if it's time for a consult with an internal medicine vet or an oncologist that will be more up to date on treatments and dosing. You absolutely do NOT have to lock Smoky up in your bedroom after giving a dose. Just make sure you scoop the litter box frequently, especially the pee. And change out the litter often too. You should wear gloves when handling the medication. The formula for larger doses given less frequently (or pulse dosing), is based on the cat size. My two cats were larger and getting 6 mg a dose. But you do have to be careful that kitty is not getting too large a dose. There should be follow up blood tests to make sure his blood counts are still stable when on the chemo.
He is concerned that all it may do is slow down the disease
Some cats live up to an extra four years after starting chlorambucil. That's a pretty good slow down in my books.
 
The vet gave me vitamin B12 to give to Smoky once a week. Here is a pic of a 1 mL syringe. It's a pretty big syringe and instructions are to give 0.25 ml. Does anyone know where that is on the syringe? Is it halfway mark between 0.2 and 0.3 mL on syringe?
Yes, it would be.
 
I wonder if it's time for a consult with an internal medicine vet or an oncologist that will be more up to date on treatments and dosing. You absolutely do NOT have to lock Smoky up in your bedroom after giving a dose. Just make sure you scoop the litter box frequently, especially the pee. And change out the litter often too. You should wear gloves when handling the medication. The formula for larger doses given less frequently (or pulse dosing), is based on the cat size. My two cats were larger and getting 6 mg a dose. But you do have to be careful that kitty is not getting too large a dose. There should be follow up blood tests to make sure his blood counts are still stable when on the chemo.

Some cats live up to an extra four years after starting chlorambucil. That's a pretty good slow down in my books.
I'm still trying to decide on whether I can go the route of chlorambucil and frequent blood testing and the higher financial costs for that. Smoky is only about 7.5 lbs right now. He has two enlarged kidneys and multiple nodules on his intestinal wall is what I think the vet called them. Unfortunately, I don't have the means to consult with a specialist. I have been considering having him put to sleep.
 
More BIG HUGE HUGS Lisa...whichever path you choose will be done out of an enormous love for him. This decision really stinks, went thru this with one of my dogs 4 years ago. We didn't go the chemo route but he wasn't nearly as sick as Smoky - we did just more or less hospice care for many months.

HUGS AND HUGS and hugs and hugs,
 
His current vet called in the dosing to the pharmacy. The prescription is for 2 mg every 3-4 days which I'm guessing is twice a week. I don't know if I'm comfortable giving him this drug twice a week. They don't allow pulse dosing where I live, at least for a regular vet. I don't have the financial means to see an oncologist.
 
Has Smoky been responding to the pred. at all yet? I know you started him on this a few days ago. Was wondering if it has helped his appetite at all. My kitty started eating like crazy on it.
 
He was already eating pretty good although he does seem to be eating more now. I am wondering about giving him the chlorambucil twice a week instead of once a week
 
It's hard to know how he will respond. You can always stop it if you feel he's not doing well on twice a week. The b-12 should help him feel a little better. I know it perked my kitty up and she had been really sick.
 
Is it possible to get an endoscopy? If it isn't small cell, the drugs won't help for long if at all. Starting pred will make a diagnosis difficult. It's a hard decision. Good luck.
 
I won't put him thru getting a biopsy. He has lost too much weight and I don't have the means to pay for expensive treatment. The vet believes it is small cell going by the ultrasound. Of course, he can't be sure w/o a biopsy being done. I am just trying the meds to see if it helps him to feel better. I'm giving it a month and if he is still sick or gets worse I'll have to do what's best for him and let him go.
 
I won't put him thru getting a biopsy. He has lost too much weight and I don't have the means to pay for expensive treatment. The vet believes it is small cell going by the ultrasound. Of course, he can't be sure w/o a biopsy being done. I am just trying the meds to see if it helps him to feel better. I'm giving it a month and if he is still sick or gets worse I'll have to do what's best for him and let him go.
I totally get it. You might need more than a month if small cell. They respond slowly but once they do they feel much better.

My Tiffany had intermediate cell. I bought her close to a year and it's much more aggressive.
 
My mom is throwing a guilt trip at me now about Smoky. I just found out on Sunday the results of the ultrasound and the treatment options for him. She keeps telling me he is suffering every day and is in constant pain. I guess she wants me to not even try to treat the lymphoma at all and just put him to sleep right away.
She is not even taking into consideration that the meds may actually end up helping him to feel better. She says all the meds will do is make him sicker or not help at all. I'm not stupid and I know I will have to let him go at some point, it's cancer after all. Sorry, I'm ranting again, it's just so frustrating.:oops:
 
You may get a lot of different opinions but you have to go with how you feel about the situation. I wanted to at least give my kitty a chance to feel better and see if the meds would help. She did feel better for quite a while and they did help her for about 11 months. I knew it wouldn't be long term but for some reason I wanted her to feel better for at least a while even if I was contemplating having her put to sleep. I didn't want her to think I was giving up on her. Sounds kind of crazy and illogical but for some reason it made a lot of sense to me. I didn't want to not try. She was too frail at the time for a biopsy but her specialist was 99.9% sure of the diagnosis. With Leo I had the endoscopy done because he was not ill and is a pretty hardy cat.
 
It's not crazy at all Lillie. I feel exactly the same way that you did. I have to at least try the meds first and would like to see him feel better first. Even knowing I would have to let him go later on down the road.:bighug:Smoky is also too weak to have a biopsy done and I don't have the means to get one done anyway.
 
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I did a really dumb thing with his pain meds. :banghead:His vet told me they were pre-filled syringes so I asked about dosage. The vet never bothered to show me how to measure on the syringe. She just said the syringes were individual doses. I gave him the entire syringe full of bupe three nights in a row, each one of them is enough for 4 to 5 doses. I could have killed my kitty was my first thought.:nailbiting::confused:
The pharmacist was kind enough to put water in a 1 mL syringe and showed me how to dose for each day from the same syringe. I am so mad at myself and the vet for not making sure I knew what I was doing first. :mad: the pharmacist told me to wait 5 days from Monday to give bupe again. I'm such a terrible cat mommy, could have really hurt him or worse.:(
 
I did a really dumb thing with his pain meds. :banghead:His vet told me they were pre-filled syringes so I asked about dosage. The vet never bothered to show me how to measure on the syringe. She just said the syringes were individual doses. I gave him the entire syringe full of bupe three nights in a row, each one of them is enough for 4 to 5 doses. I could have killed my kitty was my first thought.:nailbiting::confused:
The pharmacist was kind enough to put water in a 1 mL syringe and showed me how to dose for each day from the same syringe. I am so mad at myself and the vet for not making sure I knew what I was doing first. :mad: the pharmacist told me to wait 5 days from Monday to give bupe again. I'm such a terrible cat mommy, could have really hurt him or worse.:(
You've had a lot of stressful things on your mind, Lisa. Mistakes happen, especially when we're dealing with a lot but he survived this. Was he extra slow and dopey when he was given that much bupe? I hope you can get more bupe to replace what you've used and I'd fault your vet for not explaining clearly. When I had bupe for Teasel's cystitis pain the syringe was clearly marked with a black line to show one dose. They weren't prefilled, though - I had a small amount of bupe in a separate bottle.
 
He was very slow and lethargic. I had my vet call in a prescription for bupe. It's how I found out about giving him too much. I'm picking it up today but pharmacist recommended waiting until at least Friday night to give him any.
I only gave him one dose of the chlorambucil in Tuesday night. He vomited up some food on Wed morning and twice this morning. I gave him a quarter tab of cerenia. I feel so bad for him that he is getting sick from the chemo drug. The pred is making him eat a lot more than he was.
 
I would keep an eye on the vomiting after giving chloram. If he continues this he may not be tolerating the med. Are you dosing him on a full stomach?
 
He doesn't tolerate meds on an empty stomach well. I feed him a can first and wait a little bit before giving him the pill.
 
Some kitties do, some don't get nauseous from the chlorambucil. Next time I would give the Cerenia before giving the chlorambucil, so it can block the nausea receptors. Some cats do better with ondansetron (Zofran) as their antinausea drug, some need both. Ondansetron is a human med that you get the vet to write a prescription for but you get filled at a regular pharmacy. I give ondansetron a couple hours before, with and the day after the chemo. Kitty Neko needed it for 3 days after the chemo.
 
I can't really give him the cerenia that long before giving him the chlorambucil. I get home from work and give him the chlorambucil about 2 to 3 hours after that. What if his dosing schedule is twice a week dosing? It's prescribed to give to him 2 mg capsules every 4 days. I would have to give him cerenia nearly every day wouldn't I?
 
ECID - each cat is different. You have to see how Smoky responds to the chlorambucil and dose any anti nausea medications as needed by him. Typically having anti-nausea meds on board first is best. And you'd give it daily as long as he needs it afterwards.
 
His second dose is for Saturday so it may help him to give cerenia before that? Also, a day or two after chlorambucil is given?
Smoky hasn't had any good days lately. I'm worried about him feeling so poorly
 
With Mario, I gave 1/4 of 10 mg Pepcid AC with the 2 mg chlorambucil pill. It seemed to help with nausea the next day.
That sounds like a good idea to me. My vet will be against me buying anything OTC for him. She just wants me to get everything through her clinic. Also, the cerenia is $25 for two tablets. The dose is 1/4 tab given as needed. The Pepcid AC sounds more cost effective to use.
 
ECID - each cat is different. You have to see how Smoky responds to the chlorambucil and dose any anti nausea medications as needed by him. Typically having anti-nausea meds on board first is best. And you'd give it daily as long as he needs it afterwards.
Smoky had vomited for two days after the dose of chlorambucil. I gave him cerenia which seemed to help a little bit.
 
He is coming out of hiding more than he was. He still doesn't feel well. He vomited again this morning. That's the third time since Tuesday night. I'm worried the chlorambucil is having a bad effect on him. He has only had one dose so far though. He is getting the second dose tonight. I'm giving cerenia 2 hours before that to see if it helps him.
 
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