Changing from Lantus to PZI 0- any tips please?!

[Julie and Alice]

I am planning to change Alice from Lantus to Hypurin Bovine PZI over the next few days. Does anyone using this have any tips please?

I think I will be using the U100 BID microfine syringes that i currently use with the Lantus. How do I calculate for that? Also, is there a way of roughly guessing how it it might compare with Lantus for dosing eg Does 1 unit roughtly equate in strength to 1 unit of Lantus? I realise its duration is different because of the depot with Lantus.

Is there anything in particular that I should watch out for?

Any info much appreciated, thanks,

Julie

 

[BJM]

You may note a slightly steeper curve shape.
You might try about 50-75% of the Lantus dose you were giving, since it can be a steeper curve.

If it is BCP PZI, as you collect test data around the nadir, which can be slightly earlier than Lantus (ex +5.5) , you may be able to develop a sliding scale.
If it is Hypurion PZI, there is overlap so you'll want to stick to stable dosing every 12 hours.

What concentration is the PZI? If U-100, the syringes measure identically. If U-40, then each half unit mark equals 0.2 units (40% as concentrated, so 0.4 * syringe mark)

Carl found this info on Hypurion Bovine PZI

 

[Rachel]

Welcome to PZI! BJ gave great info so I just wanted to say yes we are out here!

 

[Elizabeth and Bertie]

Hi Julie,

Well done for 'biting the bullet' and trying another insulin. We're keeping fingers and paws crossed that this will work well for Alice.

BJ's suggestions about dosage look good to me.
It seems best to be conservative initially.

Yes, the syringes are just normal U100 syringes.
The insulin is a suspension so the vial will need to be rolled gently to mix it.
The manufacturers recommend keeping the syringe in place (when giving the shot) for 5 seconds. (I don't know why! But I find it a very helpful practice anyway...)

It's hard to say whether a unit of Lantus is (or isn't) equivalent to a unit of Hypurin. Because, while 'a unit is a unit', the real issue is how the cat responds to any given insulin.

As with Lantus, Hypurin is a long lasting insulin. So you already have experience of an insulin with a long duration and overlap. And you know that the insulin given in the previous shot can affect the potential of the following shot.

The nadir may be different with Hypurin. It may be earlier or it may be much later (there doesn't seem to be a 'typical' nadir). I'd suggest you switch insulins on a day when you have the time (and the energy) to track what the BG is doing.

Good luck with this new chapter in Alice's diabetes story! We're here cheering you both on! :thumbup

Eliz