I came across this link on the Feline CRF group earlier about cats' limitations when it comes to metabolizing drugs and pollutants. It mentions phenolic compounds:
From the article:
"The domestic cat (
Felis catus) shows remarkable sensitivity to the adverse effects of phenolic drugs, including acetaminophen and aspirin, as well as structurally-related toxicants found in the diet and environment.
Between- and within- species differences in the capacity to metabolize and eliminate drugs and other xenobiotics from the body are typically substantial, complicating the effective use of drugs, as well as
minimizing the ability to predict the adverse consequences of environmental pollutants. Slow metabolic clearance leads to enhanced adverse drug effects and
the bioaccumulation of pollutants, while fast metabolic clearance minimizes beneficial drug effects. One extreme of the species difference is the so-called ‘species defect’ of drug metabolism - a drug metabolic pathway that is common to most species, but essentially absent in one (or perhaps only a few) species.
Perhaps the best known example of a species defect of drug metabolism is the inability of domestic cats to metabolize drugs and structurally related phenolic compounds by glucuronidation [...] Glucuronidation is catalyzed by the UDP-glucuronosyltransferases (UGTs), a superfamily of conjugative enzymes predominantly found in the liver that transfer glucuronic acid to a drug (or other chemical compound) yielding a nontoxic, more water soluble, and readily excreted glucuronide metabolite
[8]. Slow glucuronidation of acetaminophen [paracetamol] and acetylsalicylic acid (aspirin) account for the
slow clearance and exquisite sensitivity of cats to the adverse effects of these drugs compared with dogs and most other mammalian species."
Link:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065456/
Mogs
.