? Bupe and raised glucose?

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BellaBlue82

BellaBlue82

Member Since 2021
Hi all,
It's been a while since I've posted.

Quick back story: Nico had been doing well on prozinc, and Amlodipine for his HBP. However the poor guy gets recurrent UTIs. This past one in October was fairly bad, I think mostly because I did not catch it in time. He was prescribed Baytril which I found out is very harsh. Since he stopped, he had been lethargic, no appetite, vomiting and diarrhea. I was trying to mitigate this with Cerenia and mirtazipine, just not a lot of luck. After a third visit to the vets and a fecal test, we found he has nothing left in his GI tract - his stomach and such were just so inflamed since he lost all his flora.

We're on the mend now, with Cerenia, mirtazipine, pepcid, ringers bag refill, B12 shots, Biome food, pro and prebiotics, and bupe for his pain. What I noticed though is his sugar went UP after the administration of bupe! Has anyone else encountered raise BG after pain meds? PS it is the liquid form.

The good news is I think he's much better now than the past two weeks, so I'm waiting to see if he does well tonight. If all goes well, I'll hold off any other doses of bupe.
 
Tagging a prozinc user for you
@FrostD
Melissa looking at the SS do you think an increase is needed, but what do I know
Looks like she needs to get more tests for both cycles especially after PMPS dose
 
I used transdermal BUPE on a Caninsulin cat daily for two years with no effect on his numbers. I never did get him regulated but his numbers were more likely to be low rather than high. The transdermal made his life so much easier, he just hated oral meds.
I don't know how BUPE affects the GI system but I felt better giving him bigger doses of the transdermal instead of liquid. We also had two cats with never ending UTI's and that all stopped when we switched to Royal Canin urinary tract wet food. Those were not diabetic cats so I never checked the carb counts.
 
I suspect it's not the bupe...

I suspect it's a combination of the food (higher carbs) and not feeling well. Did they do a culture after baytril course was complete to make sure UTI is gone?

I would also double check ingredients on the pre/probiotics for sugars
 
Neko was on bupe (liquid form) for a couple years. Her numbers actually went down with the bupe, because pain can raise the numbers and helping pain thus helped. Neko was regulated, so I could see the impact of any meds she took. If you get bupe compounded (which I did and it was chicken flavoured), you can ask the pharmacist to make sure there are no carbs in the suspension. If it's the bupe you get from your vet, then it should be OK.
 
FrostD said:
I suspect it's not the bupe...

I suspect it's a combination of the food (higher carbs) and not feeling well. Did they do a culture after baytril course was complete to make sure UTI is gone?

I would also double check ingredients on the pre/probiotics for sugars
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I'm curious if that is it as well. Sadly he's not interested in his typical food, and I've resorted to feeding him Fancy feast gravy lovers chicken and liver.

That's what makes me mad, I brought them both a stool and urine sample, but I don't think they checked the urine sample. :mad:

On the other aspect, he's sadly still having bouts of real watery diarrhea so I'm sure that does not help either. I'm going to adjust his dose just a bit for now, as long as he's eating I don't see the harm.

High number again this morning, so I'm going to push them again to recheck his urine. I will say he is certainly acting more normal, he played with me this morning and came up to get his purrs in. Who knows? I wish they could talk! Lol
 
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Oh, I also checked his pre/probiotics, it's Jarrow S. Boulardii, but I'm not sure if there is added sugar in them? I didn't see anything on the label, but I know sometimes cellulose is a filler.
 
BellaBlue82 said:
Oh, I also checked his pre/probiotics, it's Jarrow S. Boulardii, but I'm not sure if there is added sugar in them? I didn't see anything on the label, but I know sometimes cellulose is a filler.
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I use the Jarrow Boulardii with MOS, that's been fine for us. But sounds like you can increase amount of he's still watery

Boulardii is mostly good for diarrhea, not necessarily much else. He probably needs the other strains...Visbiome and Proviable are some popular ones here

Yes eating is most important, insulin can be adjusted. Be sure to check ketones as well, it's a risk at the moment.
 
Mc also was on bupe off and on for chronic pancreatitis and if anything it helped his bg because it helped his pain that can raise bg.
 
Thanks, yes I have been checking his ketones and so far ok! Fingers crossed. I did give him a very small amount of bupe in the cheek this am, so hopefully that may help.

I literally just ordered Proviable too! I'm going to add that in with the S. Boulardii, maybe do half of each.

I'll be taking a urine sample in to the vet tomorrow as well just to ease my mind. ❤️
 
Has he had his B12 levels checked? S. Boullardi isn't effective if they are low.

As an aside, Proviable contains maltodextrin, which is a carb. It is recommended that diabetic people stay away from it.
 
Wendy&Neko said:
Has he had his B12 levels checked? S. Boullardi isn't effective if they are low.

As an aside, Proviable contains maltodextrin, which is a carb. It is recommended that diabetic people stay away from it.
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Hm, no he hasn't but I have been giving him B12! I was able to take home a small bottle from the vet. I will keep that in mind. Thank you for the tip about the Proviable, I'll keep my eyes on his numbers.

Ironically today his numbers came down! I give him a mini dose of bupe in the cheek, and I didn't leave out any gravy food in the automatic feeder. Now I'm questioning if it was truly a combination of the pain and the food making his numbers high. I'm still taking a urine sample to vet tomorrow, but I do feel better that it came down today!
 
Wendy&Neko said:
Has he had his B12 levels checked? S. Boullardi isn't effective if they are low.

As an aside, Proviable contains maltodextrin, which is a carb. It is recommended that diabetic people stay away from it.
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Really Panzer & Spook have been on provibial DC for months..interesting. What do you suggest using?
 
I've used Visbiome. But you should look at Panzer's spreadsheet at the time you started using Proviable, and see if it made a difference. There may not be enough maltodextrin in there to make a big difference. Also, what is recommended for people doesn't always go for cats.
 
Great news! Urine culture came back, UTI is all gone! :cat:

We've pinpointed the BG to his current discomfort with the GI tract, and the Rx food/gravy food combo.

He's still having the runs sometimes, but I have seen an improvement in his poo. We're just going to stay on track with the Proviable, S boulardii, bupe, and B12. Hopefully this will help get his GI tract back up an running normally soon.
 
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