Buddy hypo'd, off schedule

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Marci and Buddy

Member Since 2009
I have been testing at +10 , only to find he's already in 300's , so i shoot- hard to wait 2 more hours at that #.
Now he has me up at 3 a.m. and i am not even sure at this point if that's his amps or pmps- totally confused,
sometimes shooting at +10, other times at +12.
Today at +11 he was 219,i waited an hour and shot,but shortly therafter he was 36(after HC3oz. and karo!! ).Is he so erratic because i know if i shoot early it's like a dose increase, but what should i do if he's yellow or red at +10???
should i do 12/12 regardess of the #'s? Help appreciated.
 
Marci and Buddy said:
I have been testing at +10 , only to find he's already in 300's , so i shoot- hard to wait 2 more hours at that #.
Now he has me up at 3 a.m. and i am not even sure at this point if that's his amps or pmps- totally confused,
sometimes shooting at +10, other times at +12.
Today at +11 he was 219,i waited an hour and shot,but shortly therafter he was 36(after HC3oz. and karo!! ).Is he so erratic because i know if i shoot early it's like a dose increase, but what should i do if he's yellow or red at +10???
should i do 12/12 regardess of the #'s? Help appreciated.

Hi Marci! Buddy is a hard one! That low number warrants a slight decrease, but because you shot early last night then that would mean the dose was more than one unit.

It does look like the insulin is pooping out though and I don't blame you for wanting to shoot those pinks. I would hate to see Tigger sit there for another two hours too.

I think you really need to consider that dental. Not what you want to hear, I know. I am procrastinating taking Tigger in for just a checkup!

I seem to remember Buddy had a dental once before? I couldn't find it on your SS.

How is his appetite? Is he eating okay? What is he eating these days?
 
Hey Pamela--i do think you hit the nail on the head---he is overdue for a dental.
His last one was almost a year ago, and th e vet said he'll need one every year.
At least his appetite is ok , he likes that Paul Newman stuff now, he eats about 4-5 oz. per day.
Guess i'll decrease slightly tonight, he sure does like to keep me on my toes.
Maybe it's karma coming back to me from when i was a kid :twisted:
 
Why did you shoot early 3 days in a row? was that just because you thought he was too high? I honestly think those highs are from rebound, so shooting early only compounds the problem (swings from high to low and back).

1.25u is too much and the 1u shot early is at least equal to that. Maybe try .75u and stick with 12/12. Shooting early to counteract highs is counterproductive at this point.

Do you know what the carb count is on the Paul Newman food?
 
yes, i was shooting early because of the high #'s,very hard to sit and wait 2 hours when he's over 300 , but i do see how it could be counterproductive.
Tonight i gave him a thin 1u...should i stick with that now, or
go to .75 in the morning?
Newman is 7%fat, protein,9%. Actually, glad you asked , i didnt realize it was that high.i thought because it's organic it would be lower, but looks like i'll have to find something else to mix into his raw rabbit. Thanks very much Sheila.
 
I understand about not wanting to see 300s, but in this case it really looks to me like they are caused by rebound - plus it gets him off schedule which also effects the numbers.

I just looked up the ingredients for the PN organics canned cat food and it doesn't look too bad, carb-wise, but the fat might be a little high for some cats. Wish we had the as feed amounts, but the percentages are very similar to the Friskies I used to feed and those were in the 6-7% carb range, so I would assume these are in that range also.

If you are shooting a hair less than 1u you could probably stay with that and let this all settle - 3-5 days and reevaluate. I suggested .75 because it is easier to draw. Keep in mind that for fine tuning the dose on lev will work best with very small changes of .1u.

I sure hope lowering the dose can get him off the roller coaster ride. he has been on.

BTW, what was his PS tonight? I would expect a higher number from the low combined with karo......
 
Hi Marcy,
I agree with Sheila about going to .75U, but if you continue the thin 1U just watch for anymore greens followed by pinks after a few days on thin 1U.

He looks like he's been getting a bit more than he should be recently - lots of bouncing going on - so it's good that you lowered to 1U, but giving shots earlier is like a dose increase (it is why when I do that for Gandalf because of my schedule I always give 15% less) so kaboom, he went low on you.

I think that's already been covered though. ohmygod_smile I'll stop repeating what everyone else said.
 
I went to a fat .75, b/c in the past .25u changes have proved to be too much for him. i have become good at measuring, and i can do .1 incremental doses ok-
i'll follow your idea, Sheila ,of sticking with it for 3-5 days and see.
However, in the recent past, i started with .50 to find his ideal dose, and .75 was too little. Does the "ideal dose" keep changing? Today Buddy is red, to be expected after yesterday,poor guy has no interest in breakfast and is tired. I am doing my best to help my dear Buddy and i keep trying, and I arrange my life schedule around his needs, but i dont seem to get it right.Frustrating...thank G--for all of you here!
 
Marci and Buddy said:
Hey Pamela--i do think you hit the nail on the head---he is overdue for a dental.
His last one was almost a year ago, and th e vet said he'll need one every year.
At least his appetite is ok , he likes that Paul Newman stuff now, he eats about 4-5 oz. per day.
Guess i'll decrease slightly tonight, he sure does like to keep me on my toes.
Maybe it's karma coming back to me from when i was a kid :twisted:

Oh darn, I wanted to see what his numbers looked like right before and after his dental but the numbers aren't on your spreadsheet for that period. I seem to remember you saying something about why this was but can't remember. Oh well.

Poor Buddy not feeling good today. :( I hope he comes down from that crappy red number this AM. :(

Have you tried the Wellness Healthy Indulgence pouches for Buddy? They are low carb and have some gravy in them which I sometimes use to mix with Tigger's raw if he is having a picky day. You can go to this site and find a store locator near you (at the bottom of the page).

http://www.wellnesspetfood.com/products.aspx?pet=cat&ft=4
 
Yeah, ideal dose can and will change over time. Just look at Pamela's Tigger coming down from something like 4u to 2.5u (is that right, Pamela?).

But I don't think you have found his ideal dose yet. He has been bouncing a lot for the past several months (at least) so his body is confused and it probably has a higher set point for BGs right now (still). I think what needs to happen is an evening out of the numbers, less swinging, even if those are somewhat higher numbers with no greens. Then you can very slowly increase to bring down the entire cycle.

Not sure the .5u was held long enough when you tried it. In looking at the previous .75u dosing, his numbers did start to flatten out. But then there is a little swinging starting. A 415 one day and a 93 a few days later. That is looking like rebounding. Let's see if that starts to happen again on the .75u which would mean decrease, not increase.

The 447 today is hard ot see, but was expected after yesterday - as you noted :YMSIGH:
 
Thanks Pamela for that site , and Sheila for looking into PN food count, i appreciate it.
So, what to do if Buddy is +10 and red? would an early dose reduced by 15% vs. waiting 2 more hours be better than waiting? what do some of you do :?: Thanks.
 
I know we all hate red numbers. But red numbers are appropriately colored - they are a warning sign. Cats on insulin should not have red numbers, but they do, heck, even Gandalf does. But not at the frequency that Buddy is. So why is he having red numbers?

We repeat this till we're blue in the face ('cause blue is what we want) but green numbers followed by red numbers in the same cycle or next cycle are a pretty sure sign of too much insulin, unless something else happened like not eating.

This is also why I get so frustrated with Tilly - it works, but for cats like Buddy it makes little to no sense and just makes it more frustrating for the caregiver.

Marci, I hate seeing Buddy go through this constant swinging. I worry that if you lower the dose to something appropriate (meaning what you can work up from) like .25U that the resulting numbers will cause you concern and you may continue to dose early. It just doesn't work for the purpose you intend it to, which is force the numbers down. Unlike faster acting insulins, Levemir is very stubborn, you can't force it to do that.

Buddy's been diabetic for quite a while. Has he ever had ketones? I don't see any mention of them on spreadsheet. If not, most likely he's in pretty good shape for you to lower dose low enough to stop the swinging and allow a "reset."

It's sometimes confusing because we talk about cats who are used to higher numbers and once they get to a good dose, they start this swinging thing ( which is going from high to low back to high numbers again within 1 or 2 cycles). That's not Buddy, he's producing the typical rebound cycles, but his BGs need to be stabilized. Although the cycle you saw yesterday had some yellows in it, that's still an effect of his hard rebound off the 35.

There's a possibility he can do better on .75U so I'm glad you've stayed with that and you might stay with .75U for a few more days to see how it works for him, but please try to resist giving an early shot, it just messes everything up and you'll be confused by the results.

I hope this came across with urgent concern. I want to help you understand, not make you more upset, 'cause I know you must be worried for Buddy since you're trying anything you can think of to get his BGs down. Levemir needs coaxing sometimes and I know that's very hard to understand when the meter blares a 430 back at you.

:YMHUG:
 
Vicky, thanks very much for your thoughtful reply. First , he has never had ketones,so tha'ts good.
I hope you remember back 3-4 months ago i did attempt to "reset" the dose , starting at .50u.
That was a disaster,i only strated to get decent #'s around 1u. Otherwise, he was red and pink mostly.One problem i'm having now is that he no longer has the same appetite he had before. As of a few weeks ago, he seems to require 3-4 oz. per day- he always ate twice that amount.
also, he is still happy and funny, but he seems to be sleeping more(how much does a 15 yr.old cat sleep?)
He did lose his friends to a move 6 weeks back and now has no feline campanions to play with, so much less excersize.
Hard as i try to engage him in playful running, he seems bored. :roll:
So, given theses facors,it's been especially hard to reset his dose. i get greens and blues with 1u.
but then red at the end of cycle.
Is that rebound or an empty stomach? Right now he's on Fat .75u and it's not doing it, 200's-300's.
I know if i go down in dose he'll get worse. if i go up he rebounds. ohmygod_smile
Seems like my choice is to get green/blues with rebound or high flats, think i prefer the first.because its less damaging(??).
I'll stay on this dose awhile longer,and let it settle but then i'm lost. And yes, you're right- it's totally frustrating, and disheartening to see my dear Buddy at 400. :cry:
 
Marci, does Buddy still need a dental? I seem to remember that being an issue, but with two Marcy/i's and two Buddy's I'm not sure I am remembering correctly... :roll:

Anyway, I am not really sure that you gave a lower dose a chance back in March. I don't see any dosing at .25u, just a few days (3) on .75 following a hard rebound.

There are indications that he is getting too much insulin still. Numbers at or below 40 warrant a reduction. In the Tilly protocol it calls for a .25u reduction. In the last 13 days he has had 6 dose changes. Plus those early shots and 2-3 incidences of definite rebound (400s following below 50s - two of them below 40). Last night he could have gone (probably did) low after that 109 at +3 which caused the 400+ for this morning's shot -which was early again? Or did you not test at +12?

All of those things make it really difficult to see patterns or for things to settle.

Honestly, I don't think you are going to see an end to your frustrations with how things are going. He either needs the dental, and/or he needs a true start over at .5u that is shot as close to 12/12 as possible and held for 5 days. Then you might see a pattern start to develop. Test for ketones if you want extra assurance that he is safe, but you have to give the insulin the chance to work without dose/schedule changes all the time.
 
Your point well taken,Sheila,i know i need to dose more consistantly,and have been back to exactly 12/12 for 3 days now. i did raise to a thin 1u, and blues came back-hope he won't rebound too much. Plan to decrease rather than increase if this dose dosent help-how does that sound? As per dental-vet did reccomend cleaning once a year, which is about now.Thanks very much for your help.
 
Marci and Buddy said:
-how does that sound?
Well....let me ask you this? What was your thinking in raising the dose? Are you not "seeing" the below 40 numbers on both 1.25u AND 1u doses? Are you not looking at that 109 at +3 the other night followed by a 419 at +11 (on .75u) and wondering "how low did he go"? Why would you want to return to those doses? And why do you think THIS time that dose will NOT cause higher swings and bounces?

I think you are seeing one isolated number, that happens to be a red color and reacting to it. You can't dose lev that way. You have to look at the entire cycle. The only type of number you should react immediately to is a very low one - and Buddy has them. Dose should be reduced each time.

I am sure this is coming off as harsh and I apologize for that. I just don't know what else to tell you to make you understand why he is rebounding and why he needs less insulin, not more.

Yeah, you got blues - out of one cycle. The fact that it happen a few hours after the raised dose off a 492 indicates there was no shed that needed filling. You got a 300 point drop in 5 hours.

Those kind of swings can't "feel good".
 
Sheila,I appreciate your concern-maybe i should have explained more what i was thinkning...I raised him to a thin 1u, (not 1 or 1.25) because i needed him to have some releif from the reds and pinks.
He felt alot better all day in blue,which he had for most of the day. Buddy is VERY sensitive to adjustments and .25u changes is WAY too much for him. Plus, i do think i remember in one of your posts 2 months ago , you wrote that it may be a good idea to experience the same dose after a drop below 50 before chnageing, which has worked for Buddy.
i can not tolerate his high #'s when i work from 50u up, i thought i'd try the other way, from 1 down, that's all. Anything under a thin 1 u works only for a brief time , maybe a few days ,then he hits high flats.Just thouht i'd try something i havent before, in an attempt to help him.
 
Marcy, the problem is that he is high BECAUSE he is getting too much insulin. Raising the dose to deal with the high numbers is like trying to put out a fire with gasoline.

I found this page on Somogyi rebound on petdiabeteswiki very helpful. http://petdiabetes.wikia.com/wiki/Somogyi_rebound

I had to read it several times before it really "clicked" for me, but this paragraph made it all makes sense to me:
A typical rebound pattern, most often seen with long-acting insulins, is a high, flat, unresponsive blood sugar over a period of days. Sometimes, often when raising dosage, this high flat curve will be punctuated by sudden drops to very low values, (with possible hypoglycemic events) followed by a fast return to high unresponsive numbers. (It's the sudden dip that distinguishes this pattern from inadequate insulin, but it doesn't always happen.)
(I added the bold there)

I don't believe you will see a stop to the 300s and 400s until you get below .5u, maybe as low as .25u.
 
Sheila, could you please explain why you think it's rebound?There's
no sudden dip-he's all high flat, which is why i think it's inadequate insulin.
i look back and see he did his best at thin 1.5, in may.
If you think it will help to reduce, i will,and i know Vicky agress with you, but i wish I understood why it's rebound now, since he is not high and low, just high.
My problem with going to .50 is that we tried it a few months ago and he felt awful till we hit 1u,i'm afraid that will happen again. I gave it enough time , 6 cycles and he still felt terrible. if i understood why it may work this time, i'd feel alot better going there.i'm sorry for being a slow learner, :oops:
and thank you tremendously for your patience and time .
 
:YMHUG: Hugs again, Marci.

You are not a slow learner! This stuff is hard! It's hard for us to explain well too, especially given the typed communication. We can't make a comment and you immediately respond or ask another question, it's almost like talking with tin cans!

So I got a couple Wellness cans, punched holes in the bottom and put the string through. I'm tossing yours now. Did you catch it?

Ok, here we go.

What you're seeing is exactly what the Pet Diabetes Wiki explains as high flat curve, it's just that the lows aren't evident because they can be so sudden you may not always catch them. I guarantee he had at least a 40 the other night to produce that 492 for which you wrote, "never higher AMPS" in notes. Yes that sucks. But it's a big clue, even when you aren't testing the actual low.

Sheila explained what she saw in those cycles very well. I like to call those kinds of spreadsheets the ones with the pretty colors. In one week he has every color in the range, except for 500, but he practically did. Too many pretty colors means rebound.

So the reason it's better to lower the dose considerably than try to slowly go down in dose is because of the "shed" effect. I believe I explained this to Melissa and Celle recently. Let me find that post and I'll come back and edit this one to include that.

Vicky & Gandalf said:
Melissa and Celle said:
I'm just confused. Why is it that we think 0.7 will be different now than just a few days ago?

Oh, Melissa, that's a VERY good question!!

I suppose the best way to explain it is the "shed" theory. Because Levemir has to build up in the system so that you create enough "shed" to maintain steady numbers, you also cannot overflow the shed, so if you're giving too much insulin and overflowing the shed already, you have to drain the shed a little and work on refilling it, making it easier to not overflow it! So although .7U might be a good dose, if you had continued to do .7U and the shed was still overflowing, you wouldn't be able to tell it was good.

By dropping well below the point at which the shed overflows, you allow the system time to drain the excess and essentially start over. That's why you're seeing steadier numbers without rebounds now, even though the numbers are higher.

Hope that makes it clear as mud!

So that's why Sheila is recommending dropping the dose down to as little as .25U. If you don't think he would handle that well, then go down to .5U. You need to drain the shed and in order for it to do that he will just have to have higher numbers, they should be steadier numbers but high like in the 300s. It might look like a disaster, but I've said this to others - Gandalf has been diabetic for 6 1/2 years, on Levemir for soon to be 4 years and he still gets 300s even the occasional 400 because I can't keep to that 12/12 schedule. He is 18 and he's doing pretty darn good, despite other health issues which are far worse to his overall wellness than the diabetes unfortunately. 300s are not the end of the world.

Right now you're still seeing the high, flat curve effect of rebound, so I'm sure this doesn't make a lot of sense. Everyone's impulse is that XX isn't working, so we need more insulin. Our society is obsessed with more, more, more, so we're conditioned to think that more is better or more will work. Unfortunately it does not with insulin, especially Levemir.

I don't know how else to convince you that less Levemir can be better effective than more.

Did the tinned cans work? Did you hear me?
 
:lol: Only you, Vicky, can make me laugh out loud when it comes to Buddys glucose levels! Thank-you!
We're on our way to the country now, it looks like we'll be doing another shed emptying out when we get back.
thanks everyone,for all the help--enjoy the weekend.
 
Marci and Buddy said:
:lol: Only you, Vicky, can make me laugh out loud when it comes to Buddys glucose levels! Thank-you!
We're on our way to the country now, it looks like we'll be doing another shed emptying out when we get back.
thanks everyone,for all the help--enjoy the weekend.

I do what I can. o:-)

You too!
 
Since Celle's results seem to be somewhat relevant, here's another way that I've been looking at her data: Here are all of her preshot values plotted with time (each unit on the x-axis is 12 hours). The changes have been so gradual, it's hard to tell if things are improving just looking at the spreadsheet. You can see there's a slight decrease according to the trend line. I'm not sure if that's a statistically significant decline, but at least it isn't increasing!
 

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Yes, graphs can make the data even better. That is interesting. We don't place a lot of weight to preshot numbers, but the fact they are declining for her is encouraging.

BTW did you realize you posted this in Marci's thread?

I bet you're doing this now ohmygod_smile
 
Vicky, if I were a lawyer I would say you "opened the door" by quoting your post to Melissa, she was just chiming in that her chart supported the concept.

And thanks also for explaining what I meant better than I could have - certainly over the past 48 hours when my brain was being cooked by a high-ish fever.

I will say that I think .5u might not do the trick, Marci. You may need to be prepared to lower from .5u if that is where you decide to drop to. It won't take as long to empty the shed from .5u to .25u as it would from where you are now. When I recognized Beau was rebounding he was on .5u (I had been seesawing from .5 to .4 and back and forth) and I reducing him to .3u in one step from there and it was a pretty fast step down at that point. The numbers just kept dropping and I kept reducing.
 
Sheila & Beau & Jeddie said:
Vicky, if I were a lawyer I would say you "opened the door" by quoting your post to Melissa, she was just chiming in that her chart supported the concept.

That's right. I thought Celle's data might be helpful in trying to decide what to do with Buddy.

Vicky & Gandalf said:
We don't place a lot of weight to preshot numbers, but the fact they are declining for her is encouraging.

Why aren't preshots important? Don't we need to keep them to an acceptable low? They're also the surest sign of a rebound.
 
The way I think of PS number is that on lev you can't just look at them and react to each one like you can on a faster acting insulin (where you still need to know the nadir). Lev is about the overall curve. Is it gentle, flat, steep, high, low, etc. All of it determines how you change the dose.

I think you want to keep the curve to an "acceptable" gentleness - where the lows don't cause highs. Rebound is mostly seen in the PS, true, but sometimes the high points of rebound (and the lows that trigger them) are somewhere other that at +12 or +6, respectively. Someone here just had a 500 at +9 or something and by shot time the cat was down in the 400s. Wish I could remember who that was :roll: . I read it when my brain was being pressure cooked :oops:
 
Sheila & Beau & Jeddie said:
Someone here just had a 500 at +9 or something and by shot time the cat was down in the 400s. Wish I could remember who that was :roll: .

That might have been Celle! (She did that on 6/27).
 
If it was me, I think I would drop to .25u and rule that in or out once and for all. Let it settle for 5 whole days - not 3 and then raise, if needed, in .1u amounts. Actually, dropping to .2u and raising in .1u amounts might make more sense.

You hold the syringe. What do you feel comfortable doing?

Whatever you do dose-wise, it's time to start a new thread - this one is too long :mrgreen:
 
Sheila & Beau & Jeddie said:
Someone here just had a 500 at +9 or something and by shot time the cat was down in the 400s. Wish I could remember who that was :roll: . I read it when my brain was being pressure cooked :oops:

Jack just did that on 7/7...he was 513 @ +9, then 380 by +12. :-)
 
Gee Sheila...i don't know why you can't keep all these spreadsheets straight!! You probably only look at 50 a day....lol.
 
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