BG numbers advice/remission?

Glassgoblin

Member Since 2018
Electra is on Senvelgo, and the manufacturer says to determine remission you stop giving the med and continue monitoring blood glucose and ketones. If it stays normal, you are good to stop. If the numbers rise, and no ketones, you can start the med again with no trouble.

This is my issue- after the last appointment we (Vet and I) thought that Electra should keep getting the medication until after her dental appointment on Aug. 5th. That is about 2 weeks away. Her +3-5 after dosing has been getting lower and lower recently though, even on a reduced dose (typically 4lb to her 10lb weight). Her pre-dose tests are not bad, but higher than a normal number. Usually those tests are at a time when she has not eaten for a couple hours, but the food is always available and if it is one of my later days (I get done with work 3, 330 or 430 each week) there is a chance she ate before I put out the fresh food. Our schedule is typically- I put out the fresh food after work and test her at the sink so she can drink, then I carry her to food, she eats, and then gets a dose soon after.

The advice I am looking for is about numbers and trends. I asked the Vet about the possibility of bouncing numbers, but she didn't think that was happening. I am wondering if I should skip doses on the days where she is so close to 120 or below. If it is a normal bg, or very close, would you skip? Barring food removal (with three cats and no help at home, and automatic feeders that cannot remove food from the dish) is there an additional time you would want to test in addition to the pre-dose and +3/4? Does it mean anything that her +4 test is close to the same numbers when the pre-dose test can be 30pts different? Maybe I need to ask other questions? Does anyone know how the dental will (possibly) affect blood glucose if she is going into remission? Dental is needed- broken tooth and inflammation issues, so we can't postpone.

I worry about the potential of a hypo as she gets lower numbers in the evenings. Senvelgo should start working within 30 minutes of the dose, and has a half life of 3.7 hrs per the manufacturer. I think that means that after 3.7-4 hr post dose the numbers should go up, not down as the medication reduces in her blood. Her pre-dose tests are usually +22/23 hrs after the last dose. I have not seen any signs of a hypo yet, but with our current heatwave she has eaten a little less and often is sleeping under beds where I can't watch her for symptoms. Today I got a test an hour before our usual dose time, because she was about to start eating after sleeping for a couple hours, and that was a 105. Testing her again in the next hour will have that food affecting it, right? So I think I should skip the dose today. I tested her urine for ketones after she ate and it was negative. Both times she was low and we skipped in the past she was a lot higher (but under 200) the next day, so I worry that she will be high tomorrow, but I will be away for a few hours tonight so won't be able to monitor if I give a dose and she goes too low.
 
Electra is on Senvelgo, and the manufacturer says to determine remission you stop giving the med and continue monitoring blood glucose and ketones. If it stays normal, you are good to stop. If the numbers rise, and no ketones, you can start the med again with no trouble.

This is my issue- after the last appointment we (Vet and I) thought that Electra should keep getting the medication until after her dental appointment on Aug. 5th. That is about 2 weeks away. Her +3-5 after dosing has been getting lower and lower recently though, even on a reduced dose (typically 4lb to her 10lb weight). Her pre-dose tests are not bad, but higher than a normal number. Usually those tests are at a time when she has not eaten for a couple hours, but the food is always available and if it is one of my later days (I get done with work 3, 330 or 430 each week) there is a chance she ate before I put out the fresh food. Our schedule is typically- I put out the fresh food after work and test her at the sink so she can drink, then I carry her to food, she eats, and then gets a dose soon after.

The advice I am looking for is about numbers and trends. I asked the Vet about the possibility of bouncing numbers, but she didn't think that was happening. I am wondering if I should skip doses on the days where she is so close to 120 or below. If it is a normal bg, or very close, would you skip? Barring food removal (with three cats and no help at home, and automatic feeders that cannot remove food from the dish) is there an additional time you would want to test in addition to the pre-dose and +3/4? Does it mean anything that her +4 test is close to the same numbers when the pre-dose test can be 30pts different? Maybe I need to ask other questions? Does anyone know how the dental will (possibly) affect blood glucose if she is going into remission? Dental is needed- broken tooth and inflammation issues, so we can't postpone.

I worry about the potential of a hypo as she gets lower numbers in the evenings. Senvelgo should start working within 30 minutes of the dose, and has a half life of 3.7 hrs per the manufacturer. I think that means that after 3.7-4 hr post dose the numbers should go up, not down as the medication reduces in her blood. Her pre-dose tests are usually +22/23 hrs after the last dose. I have not seen any signs of a hypo yet, but with our current heatwave she has eaten a little less and often is sleeping under beds where I can't watch her for symptoms. Today I got a test an hour before our usual dose time, because she was about to start eating after sleeping for a couple hours, and that was a 105. Testing her again in the next hour will have that food affecting it, right? So I think I should skip the dose today. I tested her urine for ketones after she ate and it was negative. Both times she was low and we skipped in the past she was a lot higher (but under 200) the next day, so I worry that she will be high tomorrow, but I will be away for a few hours tonight so won't be able to monitor if I give a dose and she goes too low.
Honestly, I’m not versed well enough in Senvelgo to give you advice. I can check with the other Moderators.
 
Honestly, I’m not versed well enough in Senvelgo to give you advice. I can check with the other Moderators.
I'd be interested in getting an opinion on the numbers even in comparison to insulin use- like, "if these were my cat's test numbers, I'd do x, y, z, or ask the Vet a, b, c."

I tested her when I got home and at +4 from usual dose she is at 140. Not terrible, but higher than normal. I could even give her a dose now, as they say if you miss just give as soon as you remember unless it is close to the next dose- and I would just give later tomorrow. Debating that, maybe just a 2lb dose/drop and test again tonight.
 
I'd be interested in getting an opinion on the numbers even in comparison to insulin use- like, "if these were my cat's test numbers, I'd do x, y, z, or ask the Vet a, b, c."

I tested her when I got home and at +4 from usual dose she is at 140. Not terrible, but higher than normal. I could even give her a dose now, as they say if you miss just give as soon as you remember unless it is close to the next dose- and I would just give later tomorrow. Debating that, maybe just a 2lb dose/drop and test again tonight.
All I know from reading is it is preferable to not miss a dose but I don’t know if there are circumstances where you would skip. Can you give it and discuss with your vet tomorrow?
 
All I know from reading is it is preferable to not miss a dose but I don’t know if there are circumstances where you would skip. Can you give it and discuss with your vet tomorrow?
I just gave Electra a tiny (it literally is a drop) dose at the 2lb mark, and will send my Vet an email tonight so she can review the spreadsheet and reply tomorrow. I'm probably lucky that I have her direct email.
 
I just gave Electra a tiny (it literally is a drop) dose at the 2lb mark, and will send my Vet an email tonight so she can review the spreadsheet and reply tomorrow. I'm probably lucky that I have her direct email.
I’ve asked any experienced member who knows about Senvelgo to pop in but I’m not sure if there is anyone.
 
I’ve asked any experienced member who knows about Senvelgo to pop in but I’m not sure if there is anyone.
It is not an emergency situation. I am just hoping to figure out how to interpret the tests. With a 24 hr cycle it is hard to know when the lowest test should be, what curve testing should be done, when to hold on a dose or wait. The last time I did this is was with Prozinc, and my cat was an only-cat, so a lot of things were easier with fasting tests, and protocols on what to do in a lot of different situations. This is the first time my Vet has prescribed Senvelgo, and only one other Vet in the office has a cat on this drug, so we are all learning as we go along.
 
It is not an emergency situation. I am just hoping to figure out how to interpret the tests. With a 24 hr cycle it is hard to know when the lowest test should be, what curve testing should be done, when to hold on a dose or wait. The last time I did this is was with Prozinc, and my cat was an only-cat, so a lot of things were easier with fasting tests, and protocols on what to do in a lot of different situations. This is the first time my Vet has prescribed Senvelgo, and only one other Vet in the office has a cat on this drug, so we are all learning as we go along.
It’s so new there just isn’t a lot of experience and most people’s vets start their cats on insulin so that prevents them from using Bexacat or Senvelgo.
 
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