Article - Sensory profile of cats with potential pain-related diabetic neuropathy
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Have you read the article? Just wondering if there is a good summary of the contents. Might be worth adding to our collection on neuropathy.
squeem3
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Abstract
Diabetes mellitus (DM) can cause peripheral neuropathy. This study aABimed to evaluate sensory function by measuring the mechanical nociceptive thresholds (MNT) and diffuse noxious inhibitory control (DNIC) of cats with diabetes mellitus (DMcats).
Eight cats with DM and 12 healthy controls were included in a prospective, randomised study. MNT were measured by applying pressure against the metatarsal pad (MNTbio). MNT were also measured using a mechanical actuator attached to one of the cat's pelvic limbs (MNTtop). The DNIC was assessed by comparing MNTtop before and after a conditioning stimulus.
MNTbio of the controls were significantly lower (2.1 ± 0.7 N) than those of DMcats (3.6 ± 1.2 N). DNIC and MNTtop were not different between groups.
This study had a small cohort of patients and an MNT cut-off to prevent injuries.
DMcats showed hypoalgesia and loss of sensory function. This study could not differentiate DNIC between healthy and those with DM.
Background
Diabetes mellitus (DM) can cause peripheral neuropathy. This study aABimed to evaluate sensory function by measuring the mechanical nociceptive thresholds (MNT) and diffuse noxious inhibitory control (DNIC) of cats with diabetes mellitus (DMcats).
Methods
Eight cats with DM and 12 healthy controls were included in a prospective, randomised study. MNT were measured by applying pressure against the metatarsal pad (MNTbio). MNT were also measured using a mechanical actuator attached to one of the cat's pelvic limbs (MNTtop). The DNIC was assessed by comparing MNTtop before and after a conditioning stimulus.
Results
MNTbio of the controls were significantly lower (2.1 ± 0.7 N) than those of DMcats (3.6 ± 1.2 N). DNIC and MNTtop were not different between groups.
Limitations
This study had a small cohort of patients and an MNT cut-off to prevent injuries.
Conclusion
DMcats showed hypoalgesia and loss of sensory function. This study could not differentiate DNIC between healthy and those with DM.