Bandit had to go back on Lantus last year after a severe bout of pancreatitis, and he also was put on prednisolone at the time (5mg/day). The prednisolone will cause numbers to be a little higher than a cat not on prednisolone, and it can cause a lot of wonkiness in his cycles (i.e. you'll find his nadirs are all over the place). As you wean him off the prednisolone, this will improve. At one point, Bandit's vet and I decided we would try to split his prednisolone dose and administer it at 2.5mg twice a day thinking that it might reduce Bandit's insulin need, but that made things worse! Instead of having one wonky cycle and one ok cycle, we just had wonky cycles all the time.
2.5 mg is a pretty low dose, so you shouldn't see too much of a problem with it. You'll find that you'll likely need less insulin once you are able drop that dose down to half that, and Bandit pretty much went right back into remission once he was fully weaned off the steroid.
We did TR back in 2009-2010 when Bandit was on insulin the first time and last year when he needed it again. The better control you can get over his BG while he's on the steroid, the more likely he is to go back into remission when it's done.
