For whatever it's worth: way before Adequan, in the late 80's, I took two cats to the vet specialists with arthritis. They were 12-yr old male sibs. From their habit of jumping to my shoulders from the floor, they could no longer jump at all, and were beginning to have difficulty walking. The vet specialist prescribed MSM, with which I was familiar as a derivative of DMSO. At that time, all that was available was in powder form. I picked it up from the vets and made capsules. A couple of years later, I was able to buy the MSM as tablets for dogs (from Valley Vet, I think: great prices and dependable ... been using Valley Vet ever since). Then MSM tablets became available from WalMart. Cheap, too. One brother died of kidney failure at 17, but the other lived to be 23 1/2. The MSM worked a miracle. Never again did they jump to my shoulders, but they had no trouble making jumps to cabinets, beds, etc. And never again any difficulty in walking. They were each on MSM until their deaths.
I now have another severely arthritic cat, more so, in fact. It is only in reading your comments that I equated my two guys from years ago with my Randall's current condition. His vet has prescribed Adequan for him, and I'm glad to read that sub Q will be OK. I have a diabetic cat, as well, so am well versed in giving those shots (though I was a bit worried about the IM business). the vet suggested in his thigh, but he has lost a lot of muscle mass, and I hated the idea. And I am going to start him on MSM!