I've been using Transdermal BUPE for years on many cats for different pains. Our last sugar cat Noah had a mouthful of rotten teeth but would never have survived the anesthesia and just hated oral meds so that added three years to his life. It never affected his numbers, never made him constipated and with every cat I've used it on we never had to worry about the stairs. Mine did leave a waxy buildup in the ears so all I had to do was keep his ears clean. Andy broke his leg in two places, same story. I've also used it short term when Marco used to get frequent UTI's. Just enough to get him through the night or make the car ride less miserable.