I need some expert opinions here. As you know, Harley is IAA positive. A quote from High Dose ISG: “When insulin is injected into a diabetic cat, the body views it as a foreign substance and the immune system sets out to destroy the "invader" insulin, just as it would destroy cold and flu viruses. When this happens to injected insulin - most of it never reaches the bloodstream thus being unable to control blood glucose. Insulin doses may be increased but the immune system only goes into higher gear and continues to effectively destroy any additional injected insulin. Over time this becomes officially known as insulin resistance.” and “IAA is supposed to be self-limiting, meaning it goes away at some point. “We have a couple of anecdotal reports of kitties who, by continuing to raise the insulin doses, were able to overwhelm the antibodies, eventually lower the insulin doses and gain control of the BG’s.”
Here is my question on Harley. Looking at his ss, he did better (achieved lower number, more often) on a higher dose on insulin. It makes sense to me that if after 6 cycles, he has not gone into acceptable numbers (100’s for me), I should be raising his insulin needs to counteract the anti-bodies. I do not want the anti-bodies to become accustom (or take over) to a lower dose that will increase his bg.
Does anyone have any thoughts on my thoughts (does that even make sense?)
Now, I don't want to make any changes until after vacation which is 7/16. I take Harley to the U of MN for a medical boarding for the week I am gone. I hate to leave him alone with only someone stopping in twice a day to shoot and feed. At the U there is 24/7 care and I can vacation with peace of mind.
Thanks
Pattie
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