Know that there are alternative dosing strategies to manage cats being given Prednisolone if you run into issues with your attempts using the protocols here. The protocols being used here were created to try to help cats go into remission vs being a means of managing every cat &/or cats with special needs such as a cat with DM being treated with Prednisolone. The problem is there is the increase in insulin resistance, and as you are seeing, more so during the cycle with the Prednisolone vs the cycle without it. Many times, attempts to manage the glucose end up being very limited if using the protocols used here—because the dosing is the same for both cycles. You end up having to stop short of maximizing the dosing for the cycle with the Pred because you then end up with lows in the cycle where Pred is not given.
The other option that has been used in the past to make it simple is to do split dosing with the Pred so that someone can use the same doses of insulin each cycle, but the issue is that this approach often results in the cat spending more time in higher #s overall and across 2 cycles vs only 1 cycle because even with the higher doses of insulin, there are still some limitations to how much of the spike you can control from day to day. Again, some days it can be better than others.
In the end, the goal is obviously to find dosing that is able to manage the insulin resistance so that the cat spends as many hours as possible with good glucose control. Often, with cats being given Prednisolone, alternative dosing is the best way to accomplish this.
If you need to or decided to do this, the Libre will help as would a consult with an endo. Just wanted to throw this out there so that if you run into issues, you know there are some options….you aren’t stuck


. Best with the increase in dose!