At the risk of being a broken record :mrgreen: I'd really experiment with shaving a bit off the dose on the lower PSs. You seem to get better nadirs whenever the PS is a little higher, and then on the lower PSs the nadir isn't as good, which suggests to me the dose may be slightly too high on the lower PSs. Today isn't bad, but the +6 is higher than the +4, when based on his previous data the +6 should be lower, so that suggests to me that *something* could be up, and a hair lower dose trial in order. I could be wrong, but it really seems worth a shot to me to see if you can get more green nadirs that way. I'll try to keep my mouth shut for a bit now. :mrgreen: