Re: 4/23 Gus AMPS HI; +1R556; +2R505
for me, it's hard to say at this point whether I think Gus is insulin resistant due to an underlying condition, or just because his numbers have been high for so long. They all build up glucose toxicity when they stay in high numbers for a while, and it can take a good bit of insulin to break through. Then when they break through, they usually will go through a bunch of dose reductions fairly quickly. So his resistance could be just that, or it could be some other condition.
We used to start suggesting acro testing when a cat got to around 5 units BID without much response. Now, I don't automatically consider 5u to be "high dose." We're seeing more cats that get to that dose (and higher) and still break through and go down the scale normally. Now I don't start thinking "high dose" in most cases until 7-8 units, unless there are other clues on the spreadsheet. In the German forum they see even more higher doses than we do (though they don't do acro testing very much, so some of those could indeed be undiagnosed acros).
Gus's super high numbers do make me wonder what is going on, but he is getting a good response to fairly small doses of R so who knows? We have seen acros who respond that well to small doses of R (Jazzy is one, and
Mouf is another). I have also seen IAA cats who don't respond well to Lantus but have a tremendous response to R. The same is true for cats without these conditions, though.
Have you read through the
What We Know sticky in the High Dose forum on this board? There are simple blood tests that can identify acromegaly and IAA, and if you are curious then it might be worthwhile to consider running those tests. I do think there is a possibility Gus has one of those conditions, but I wouldn't say it's a for sure thing. In any case, at this point regardless of whether he has another condition or not, our job is to give him whatever amount of insulin he needs and keep him safe in the process. Some cats never even get up to 1 unit, others need far more. Lucy got to 4.25 units BID before she turned around and eventually went OTJ. Randi's
Max got up to 6 units and looked for all the world like a resistant cat, and he went OTJ. They like to prove us wrong!