Eric
We've been battling on again/off again elevated ALT in Gracie for the last 2.5 years. Twice, the AST has been elevated and once the alkaline phosphatase and bilirubin have been but she's never been anemic. Wrigley's liver enzymes are not horrifically high but should be further investigated. Elevated bilirubin can be due to hepatic lipidosis (FHL) but Wrigley would have had to be anorexic or at least consuming less than 50% of his normal calories to have FHL. ECID (every cat is different) but I've seen situations where cats have consumed less than 50% of their calories for some time without getting FHL but again.....ECID.
My vet had me take Gracie to an internal medicine specialist (IM) where they did an ultrasound (u/s) and also a bile acids assay to be sure her gallbladder was not obstructed. The bile acids assay test was normal. All of her organs were within normal limits on the u/s and, at first, they felt her common bile duct might be a bit dilated from infection but then decided it was consistent with early ultrasounds she had before she was diabetic and her liver values were all normal.
Elevated liver enzymes can be tough to figure out; it can be cholangiohepatitis (also known as cholangitis) and can involve infection/inflammation of the liver, pancreas, intestines, bile duct, etc. The symptoms Gracie had were occasional vomiting early in the morning...clear, foamy vomit; drinking more water and thus peeing more. Not excessive but I noticed it. She was treated with a 30 day course of clavamox and also water soluble liquid vitamin E which is hard to find without glycerin (not FD friendly) but I found
Aqua-E and she still takes 75iu daily. The vets could never diagnose any specific problem since everything was normal on the u/s and with the clavamox and aqua-E, her symptoms disappeared and her liver values gradually came back down. Her ALT tends to run high normal now but she has had no symptoms
anti jinx for quite some time. The IM specialist said the only way to definitively diagnose what the specific liver disease is is by biopsy and we refused to do that for a kitty who was eating well and became clinically normal. A lot
of info but it might help you not reinvent the wheel or at least give you some things to ask your vet.
Wrigley is fairly anemic; a cat is considered to be anemic when the HCT( hematocrit) is less than 30%, generally, but some labs differ. His rbcs (red blood cells) and HGB (hemoglobin) are also low which definitely point the finger to anemia. The anemia is critical if the HCT is below 20%. It's important to be sure that the lab values of your lab are the same as on the lab tab. The ones on the lab tab are for Antech; IDEXX sometimes differs a bit. There are two types of anemia: non-regenerative and regenerative. Usually cats with chronic kidney disease (CKD) will have the former as their bodies cannot recover on their own from the anemia but cats with regenerative anemia may be able to correct the problem on their own. Although it primarily applies to CKD, here's some info on
Anemia. Anemia can be associated with liver disease. I would talk to my vet about giving Wrigley B vitamins. Usually 500 mcg of methylcobalamin a day (divided into two doses) and a multi B like Jarrows B Right (only give 1/10 capsule daily divided into two portions) can help with anemia. But clear that with your vet; he/she might have some other formula he/she prefers.
His kidney values look great so the anemia is not associated with CKD; I suspect it's got something to do with his liver.
I hope this helps some. Let me know if you have any questions. BTW, Gracie took denamarin, too, for quite a while and it never helped.