Re: 4/11 Noxin AMPS 302 Only gave 1 unit this morning
Hi, guys!! I just wanted to stop in and say hello and welcome!! I too had a vet that wanted me at one point to switch to once a day dosing, and it was a horrible idea that I'm glad I didn't go with. I'm no scientist, but let me try to explain WHY twice a day dosing is such a must... I'm someone who wants to make informed decisions and I know it always helps me to know the WHY when deciding what to do... especially when I've got a vet (who's supposed to be the expert, right???) telling me one thing and strangers on the internet telling me another.
Lantus is a depot insulin, which means that it is stored under the skin and drawn from in a time-release kind of way. We call the insulin storage the "shed." When you're first starting out, quite a bit of each shot is going to the shed (picture Noxin carting his little bag of insulin to a shed in your back yard and storing it there!), which is why it takes 5-7 days for you to really know what Lantus will do... because the insulin going to the shed is for later, leaving only a little insulin to be used for right now.
Once the shed is full, then each shot merely tops off the shed, with the bulk of the dose going to help Noxin battle his high BGs.
Here's the thing. Cats metabolize Lantus in 12 hours. So you give Noxin a shot in the morning, he takes some out to the shed, and then uses what is left. But then he doesn't get any at night. He'll pull what he can from the shed, but not enough to make a full amount of difference. So the numbers are higher. Then you give another shot the next day, but now even more of that shot has to go to the shed, which you depleted the cycle before. So, numbers less good... and you repeat this cycle for a week or two, and you're just constantly playing a catch up game trying to fill the shed... and suddenly, you'll get to the point where you're shooting a whole lot of expensive insulin in your cat and you're getting crappy results because the insulin isn't allowed to work the way the cat's body needs it to.
That, to me, is what is so upsetting about vet's telling people to dose once per day. You are asking someone to spend alot of money and effort to treat a cat, but are effectively sabotaging their chances of success from the get-go. Which then stresses out the pet owner because they are getting no results not because the insulin won't work, but because they are telling the owner to use it incorrectly.
I would encourage you to ask your vet about the "depot" aspect of Lantus and ask her to explain WHY she believes that once a day dosing is appropriate given it and the rate at which cats metabolize it. See if she can provide a reasonable answer. My guess is that the vet, like so many others, knows little or nothing about the mechanics of Lantus, but rather just heard that it's the latest greatest bees knees and is applying her prior knowledge of insulin to Lantus. The problem is that Lantus is fundamentally different than prior insulins (the only comparable insulin is Levemir, which is also pretty new), and those differences needed to be accounted for when creating a successful treatment plan.
We ultimately went with a different vet (the old one actually kicked me out for being non-compliant!), but many here have vets that are there for emergencies, vaccines, etc. only. My vets now are mostly supportive of what I'm doing, and neither would ever suggest once a day dosing.
If you are seeing nadirs at +12, I'd maybe suggest starting over at .5u BID. That will keep Noxin from going too low, and should allow the shed to fill with twice a day dosing. You can then go up from there if you need to.... slowly and safely.
I'm sorry... please know that folks here aren't trying to dog pile on you. We just have been in your shoes and we want what is best for you and for Noxin. While people can take many different approaches to treating this illness, there are a few things that make it next to impossible to regulate. You want Noxin regulated as soon as you can get him there, because that gives him the best chance of remission... which is the ultimate goal. Unfortunately, our experience (and science) strongly indicate that once a day feeding and dry food are two things that make it difficult, if not impossible to get there.
If you have any questions or concerns, feel free to PM any of us, and we're happy to answer! Hang in there!!