1. good question - we get cartridges of Levemir and use it to the last drop pretty much. DH keeps the empties (ugh!)
If you open and pour down the drain (the insulin is dead anyway), you could throw away the bottles.
2. "high dose" according to one acromegaly report is a cat needing more than 1 unit per lb body mass per day
So - if you have a 12 lb kitty, and you are at 6U BID --- you're at the threshold.
We recommend if you've been following the start-low, go slow method and are feeding good low carbohydrate food, and you get up to 5u BID --- time to start thinking about getting the IGF-1 and IAA tests done.
These two tests have more definite YES/NO answers than Cushings tests.
My first diabetic cat, Norton, had Acromegaly (positive IGF-1 test). At his high point, he was getting 13u BID.
Edited to add:
A vet that treats dogs may suggest Cushings tests -- Cushings is more common in dogs. We have seen here at FDMB that Acromegaly is much more common than Cushings for CATS. So... stick to your guns if you want these tests run --- these two tests are run at ONE lab in North America -- have your vet contact them directly to cut down on travel time, shipping fees and middle-man fees.