11/02 MISSY PMPS ATrak VET RESULTS???

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Maresydotes

Maresydotes

Member Since 2011
http://felinediabetes.com/FDMB/viewtopic.php?f=9&t=55331

Recap of last couple days:
10/31
271- AMPS
273- + 3
307- PMPS

11/01
305- AMPS
250- +6
317-PSPM

11/02
292- AMPS
199- +4 1/2 :-) yeah BLUE!!!
251- +10
285= PMPS

We got results from the vet. She has mildly elevated liver enzymes.
ALP= 73 Normal= 1-70
ALT= 86 Normal= 5-65
AST= 52 Normal= 26-43

My vet recommended Denamarin (SAM-E and Milk Thistle) supplement to help her liver and a recheck on blood values in 30 days.

Does anyone have any thoughts on this? Has anyone had any experience with this supplement? I have done a bit of reading on the blood values and supplement, but not a lot, yet. Any input would be welcome. I am seeing some results with the dose increase to 5 units. Th first time I have seen her in the blue (albeit it could be a meter anomaly) in a long time. :-D Her other values are lower, as well, so maybe this is the start of a good dose for her. I am sure I will have to be vigilant once I start her on the Denamarin. Kind of slacked off testing until I get started on it.

If anyone has anything to offer on this supplement and/or her blood values, I would love to hear it!!
Thanks
 
many of us use Denamarin for liver support. i haven't seen any noticeable effect on alex's blood glucose values.
not sure if your vet mentioned Denamarin should be given on an empty stomach and at least one hour before a meal time. you don't want to cut or crush the pill if you don't have to. alex is pretty easy to pill so i syringe 1ml or 2ml water to wet her whistle, pill her, and then follow with 4ml - 6ml water.

see: Pilling Cats (and Dogs) and Erosive Esophagitis, Compounded Flavored Liquid Alternatives, Transdermal Medications, Pill Pockets
 
Ann,
Thanks for the bump...I am kind of a night owl. ;-)

Jill,
Thanks for the tips on pilling. My vet did tell me about giving it on an empty stomach. I usually feed her after pilling, but I guess in this case I should just wet her whistle. I like the idea of some water prior, not just after the pill! I'm sure it makes it easier for them to get it down. Too bad they can't make smaller ones...I always worry about pills getting stuck in her throat.

I haven't really had a chance to do much reading on the ALT, ALP and AST, yet. Does anyone know what they do and why they might be elevated? The tech mentioned it might be, in part, due to her weight.

Thanks
 
Hi Mares,

I know nothing about the liver enzymes. I just wanted to say hi. I'm glad the new dose seems to be getting good results.
 
Thanks! Hopefully we are on the right track. It sounds like the Denamarin can do nothing but help her liver....a healthy liver is a happy liver :-D I know I sure am happy to see her out of those pinks.....
 
Mares, I HIGHLY recommend Denamarin for Missy's liver!
Calistica has been taking it for about 2 years now. She had seriously elevated liver values for years and Denamarin helped bring the numbers back to normal ranges.
I have to warn you about the recommendation to give it on an empty stomach. I did that in the beginning and it made Calistica nauseous. She would vomit the tablet 12 hours later and you could still see the blue coating!
I then decided to call Neutramax and they told me that I could give it to her 2 hours after a meal and that worked! So now she gets it 2 hours after dinner and then no food 2 hours after.
We are lucky that we can pill Calistica because you can't cut this thing.

Here is some info on elevated liver enzymes
http://www.vetinfo.com/causes-of-elevat ... -cats.html
Thelma
 
If your vet is suggesting supplements, my guess is that these levels are not extremely elevated. As such, take the descriptions below in context.

ALT, or Alanine Transferase: The significance of this finding is unclear at this time. This is an enzyme that is primarily found in liver cells, although small numbers of red blood cells and striated muscle cells also contain this enzyme. Elevations of ALT occur when any of these cells are even slightly damaged. Extreme exercise, hemolysis of red blood cells, and any liver problem will result in a high ALT. There are many drugs that affect the liver which can cause this elevation. Some of these drugs are glucocorticoids, Acetaminophen, non-steroidal anti-inflammatory medications (like Rimadyl or Metacam), antifungal medications, Methimazole, anti-seizure drugs, Tetracycline and many chemotherapy drugs. Hyperthyroidism should be considered in older cats. Some common causes of liver disease include cholangiohepatitis (an auto-immune disease of the liver), cirrhosis, feline infectious peritonitis, and malignancy. If the ALT is the only liver enzyme elevated, this value should be monitored, since it may be the first sign of emerging liver disease. An elevated ALT does not mean the liver is not functioning normally.

ALP or Alkaline Phosphatase: This is a liver and bone enzyme that is elevated when there is inflammation of these tissues. Any increase of this enzyme is significant in a cat and is probably coming from the liver. Common causes for this elevation are hepatic lipidosis (fatty liver disease), cholangiohepatitis (auto-immune disease of the liver), hyperthyroidism or Diabetes Mellitus.

AST or Aspartate Transferase: This is an enzyme primarily found in the liver, but also in muscle and red blood cells. An elevated AST indicates that the affected cells are severely damaged. The most common reasons for an elevated AST are liver disease, hemolytic anemias and muscle trauma, including recent vaccinations. This elevation should be interpreted in light of the other liver enzymes, hematocrit and physical exam.
 
Thelma and Calistica said:
I have to warn you about the recommendation to give it on an empty stomach. I did that in the beginning and it made Calistica nauseous. She would vomit the tablet 12 hours later and you could still see the blue coating!
I then decided to call Neutramax and they told me that I could give it to her 2 hours after a meal and that worked! So now she gets it 2 hours after dinner and then no food 2 hours after.
We are lucky that we can pill Calistica because you can't cut this thing.
Click to expand...
it must be an ECID thing. alex has never had a problem with vomiting after taking Denamarin. i urge you to try to give the pill as directed and then if it doesn't work... try an alternate method.

you're not supposed to cut the pill, but it can be slightly crushed and put in a small piece of a pill pocket if you're not able to pill missy easily. supposedly, crushing the pill will only decrease it's effectiveness by a very small percentage.
 
We give it to Gracie and her only elevated liver enzyme, ALT, is coming down. It has never affected her BG. I usually give it to her about an hour before dinner (+11) when she hasn't had anything to eat since +5 or +6 and I also give liquid, pill, liquid, and a teeny tiny bit of boiled chicken just to be sure and follow it with food.
 
hi marilyn - i don't know anything about the liver, but just wanted to cheer you on. thanks for stopping to see punkin today!

hope this dose is better for missy!
 
Thelma,
Thanks for the info on the Denamarin. I will watch to see if it bothers her or she pukes. I gave it on an empty stomach yesterday and she held it down, although I DID hear some gurgling going on later in the evening. :o

Sienne,
Thank you SO mch for the info on the liver enzymes. They are only very slightly elevated, but I still like to know what is going on. They did an additional test, and I forget what it was called, but that was normal, so whatever is going on, hopefully we caught early....and it could just be the FD.

Jill,
I plan on doing the empty stomach thing. I had to give her a bit of food after, tho. She HATES me giving her liquids...and I even have a syringe with a curved end and I can get it in the side of her mouth without her even seeing it. She just hates it. Even tried the tuna water. No go. Silly cats wouldn't even eat the tuna itself! :lol: it must be a genetic thing, neither one (her and her civvie brother, Phoenix) likes tuna, neither one reacts to catnip....
I hope the bit of food isn't bad, but I want to be sure she gets the thing down!

Marjorie,
Thanks...it is good to know her ALT is coming down. We are going to try this for a month and then recheck her values. It is also good to hear that it hasn't affected the BG numbers (good and bad). I was afraid it might affect her BG and wanted to be on top of it. I think the way you do it, at +11, sounds good, especially if Calistica had problems with nausea. Maybe a food in the tummy a bit later on will avoid the nausea.

Thanks a lot for the input...I appreciate it.
Oh, and Thelma, the vet said Missy's acne looked the best it has since we started treating it....so thanks for the tip on the shampoo!! I've been fighting acne longer than FD!
 
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