After 4u, I would be OK with .2u increases every day, or .4u every 2 days
until you see your first blue
then it would be safer to stay at a dose at least 4 cycles so you can test c3.
But this is really up to you, it's important you are comfortable. I seem to remember you are expecting small fry #2 and are hoping to get Charlie settled soon - Yes?
When you say he is a hungry guy, does he lick his plate clean pretty much every meal? Ever steal food?, or eat things you would not expect a cat to eat?
would you say he has large paws? or anything unusual about his face or jaw?
Did you ever take a look at the high dose ISG stickies? Charlie's snoring, size, sex, age, heart murmur, appetite, and slow response from almost 4u dose is not uncommon in high dose conditions like acromegaly. The only reason I even mention this at only <4u, is if you are in a hurry to get him regulated. Dose increases can be more aggressive in an acrocat, once you have a diagnosis.