Paws crosses for good results from the blood draw.
Every once in a while I search for new articles on IAA (admittedly been a little while). All I've seen is two older ones, with conflicting results (many cats have IAA, it is rare) from studies on very small numbers. It doesn't seem to make it to the top of the research worthy articles pile. MSU is, I think, the only place in the world that tests for it. When Sandy got B
lack Kitty retested years later, she got in touch with MSU and there wasn't really anything new at the time. Just found
another article - warning, info overload on detail. It's about insulin resistance, and mentions antibodies.
It is interesting because it is similar in some respects to the neurotransmitters in the brain....receptors, binding affinity and issues that can occur along the way.
I do know that Dr Mark Peterson out of NYC, who is an older but very well respected vet endo, has done quite a bit of work and co-authored journal articles and books which address the topic. Unfortunately, when I attempted to reach out to his practice for a consult last year when T was first diagnosed, they told me he now limits his clinical practice to thyroid vs general endo
.
I just ordered the textbook “Feline Endocrinology” by Feldman, Peterson and Fricassi. It’s the first book fully dedicated to endo in the cat
. Drs Feldman and Fricassi are both based out of UC Davis, which has a strong endo group/research Dept.
I was able to access some of Feldman and Nelson’s Feline and Canine Endo book online. It was published in 2004 so I’m not sure how much the info has changed. They do discuss the pre receptor, receptor and post receptor issues that occur as well as concurrent disorders that will cause issues. Very informative—especially the concurrent disorders piece.
Let me know if you have issues accessing the pages online (I was happy those particular pages weren’t omitted in the “preview”)and once I get the newly released book I will share any “new” info from I find. However, I would like to know what are they studying, discovering RIGHT NOW. What has someone tried that may be different from previous practice and did it work?
A couple of questions that came to mind after reading the info from the older Endo book:
1) What effect is the triaditis potentially having with the BG? I can’t wrap my head around how the vet said & thinks that the inflammation seen on US is probably not an “active” problem. Just because a cat is not demonstrating overtly obvious clinical symptoms like vomiting or pain, doesn’t mean the inflammation that is significant enough to show up on US isn’t “active”. Of course it’s active!! Inflammation of the intestines, let alone pancreas and liver, causes all sorts of disruption for glucose regulation and is a major factor for both humans and pets with Type 2 DM.
2) In the older book, they mention....... “Switching from the recombinant human insulin preparation to beef/pork-source PZI may improve control of glycemia if circulating anti-insulin antibodies are the cause of the insulin ineffectiveness.”
Has anyone tried this?
Again, I will let you know what changes, if there are any, in the new textbook that is feline specific and was published 2019 vs the feline/canine book 2004. I will get the book by Thursday
.
Add “Endo Roundtable” along with the magic viewer to that Christmas list
!!!
, will read through the rest of your condo when I learn how to breathe again!
Ah, I see Christie posted before me.