1/25 Ozy AMPS-327, PMPS-301

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Re: 1/25 Ozy AMPS-327

Yes, I just filled it in as 7 units. We test, put it in the SS and then after he eats we shoot and put that in the SS. Too superstitious to put it in before we shoot.

That was a quite a rise from +9....
 
Re: 1/25 Ozy AMPS-327

You increased today, with confidence that it was the right move. :cool:

How's Ozy doing in the pain dept? is it possible he needs a dose of bupe?
Anything else that may be bugging him? Any chance he got int any contraband?

Time to consider a shift into overdrive - increase every 4 cycles - if he doesn't make a sufficient course correction from this dose.
 
Re: 1/25 Ozy AMPS-327

No contraband. No unusual foods. I am a little concerned about his pooping. He isn't pooping much since all that vomiting. But if that were the issue, I don't think he would feel good and he does feel good.

He feels great today, best he has felt in a long time. He has been feeling progressively better every day since he got over his pancreatitis attack, or whatever it was. He is even moving pretty fast, which is very unusual for him. It isn't pain. I think I just let those IAA guys catch up. And, yes, I think his IAA is still active.

I wish I had tested him again last night at PMPS. Was that 112 a good reading? It's always hard to doubt good news....

An increase from 6.5 to 7 is less than 8%, it's a pretty small increase. I am worried about getting ahead of those little buggers again....
 
Re: 1/25 Ozy AMPS-327,+1-347

donaleen and Ozy said:
He feels great today, best he has felt in a long time. He has been feeling progressively better every day since he got over his pancreatitis attack, or whatever it was.
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That is good news indeed.
donaleen and Ozy said:
I think I just let those IAA guys catch up. And, yes, I think his IAA is still active.
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there is precious little out there on IAA in humans, it's very frustrating to try and understand. from the little I have been able to read and comprehend, the return of sensitivity to insulin is a sign to pay attention - a sign that is is breaking. When I noticed it with BK - I paid attention

It was 11/03/2008, below are my remarks:
AM+11.75=47, AM+12.25=110, shot 7.0u Lantus ( partial fur shot) at +13. IAA seems to be breaking - uncharted territory - playing it safe.
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That 7u btw was a BCS. It was the first turning point. Can it return? does it wax and wane? I have not read anything that indicates one way or the other.

I had him re-tested for IAA shortly after that break, expecting to see a different result. His vet said it will be the same and it was. that just makes things crazier to understand. But the world of antibodies of any sort is complex and difficult to understand.

I've decided to have BK re-tested and have an appointment on the books for next month. I need to know the results. I need to know if it will be different or the same. For the pure purpose of adding an extra piece of info to his IAA puzzle in hopes that it may help any and all IAA kitties somehow.

It's beyond fabulous that BK overcame such odds and can serve as an inspiration to others. But he is just one cat and one is not a very good sample size for drawing conclusions. I'm painfully aware of that. It is however all we have at this time and all that I can speak to.

It is not easy for me to draw a line where my experience ends or to convey my thoughts on other IAA kitties whose beans are looking for "the" answer. I don't have ''the'' answer - although I really wish I did.

Nevertheless, I offer what I can , in hopes it may help in some way, not only for individual beans of IAA kitties but also in hope of increasing our knowledge of feline IAA and how best to treat it safely.

OK - enough with the sermon. . . Now that you are on the first cycle of a new dose, and seeing some consistent pink, you may have an opportunity for another R trial.
I believe that in the absence of an R track record (meaning more than a trail or 2), shooting R at anything less than a mid pink does not provide enough wiggle room to accommodate the unexpected. Some kitties, like BK in the height of his resistance, can take a whole lot of R and the numbers don't budge. Others, like Dyanas JD, can sometimes dive with just a drop. When BKs IAA broke and he started flying down the dosing ladder, we used to joke about the contrast - in the early days (actually months - maybe even a year) of massive doses of R doing next to nothing, he had arrived at a place where it seemed I just had to 'wave the bottle over his head' :lol: Funny true, however an important fact to remember with IAA kitties.

You already know the whys and what fors of R use Are you game for another trial should the opportunity present itself?
 
Re: 1/25 Ozy AMPS-327,+1-347

Isn't it too late in his cycle for R today? His nadir is "usually" between +9 and pre-shot and and we are at +5 (four hours till +9).

I am concerned that raising him half a unit every four cycles will not be enough to get ahead since the percentage of increase is so small. The longer I leave him high, the harder it is to get him down. It's like he ratchets up. I am not going to want to leave him high for four cycles so if he doesn't come down, I want to do something.

But I don't want R to get in the way of dose increases either. Quandry.
 
Re: 1/25 Ozy AMPS-327,+1-347

Yes this cycle is not a good time.

If he is still mid-high pink at PMPS , that may be a good time for a second trial.
He does not appear to be bouncing and I don't see a history of action in the second cycle of any dose increases so far.
donaleen and Ozy said:
I am concerned that raising him half a unit every four cycles will not be enough to get ahead since the percentage of increase is so small.
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donaleen and Ozy said:
I am not going to want to leave him high for four cycles so if he doesn't come down, I want to do something.

But I don't want R to get in the way of dose increases either. Quandry.
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I can't recommend 1u increases at this point, nor can I recommend only 2 cycles at any one dose. That's my $0.02

Using R to pave the way for L. is doing something.
R sprints off the starting blocks-in hopes that L can grab the baton at L onset and head for the finish line. If that happens it can provide the latitude needed to wait out a full 4 cycles . It can give you confidence that you aren't increasing L to quickly by not giving a dose a proper chance to show what it can or can''t do. Also, if the reason for the high numbers is something bothering Ozy that is unknown to you and decides to resolve itself, that may become apparent and save you from a PJ party due to him being over dose on L
I agree that you don't want to use R to the point where you can't tell which end is up with the L and making the decision can put you in a quandary.
It's pretty apparent that I'm a one woman crusader for 'R Temperance' and it's equally apparent that massive doses of R helped BK get where he is today :cool:

It all boils down to careful consideration and ultimately your comfort level.

I've got to step away for about an hour. .Ozy could very well make the decision for you by then ,,BBL :cool:
 
Re: 1/25 Ozy AMPS-327,+1-347,+6-300,+9-241

saw his +9 - looks like he's coming down.

i agree about not doing 2 cycles and then increasing. i just don't think there's enough time to know what a dose will do in 2 cycles. the depot and the dose need the time to "equalize" for lack of a better word. I would give this dose increase a total of 4 cycles and see what it does.
 
Re: 1/25 Ozy AMPS-327,+1-347,+6-300,+9-241

Hi Donaleen,
Just stopping by to see how Ozy's doing, and I'm so happy to hear that he's feeling good today. :-D
Such wonderful news he's moving fast!
 
So, barely pink. I was hoping he would react to 7 units on the first dose like he did 6.5 units on the first dose just 4 days ago. But, no.

So, a little R? Or should I wait for morning to do R (if needed then)?
 
I think Sandy was suggesting if he was mid-pink or higher at pmps to try it then. i think i'd hold off now and see where he is in the morning - unless she sees your post and suggests something different.
 
Thank you Julie and Carl for your EXCELLENT reading comprehension. Here I was feeling like a slacker because I want to go to bed.
 
if you're tired, take it as a gift and let the Lantus do its thing while you catch up on sleep! :YMHUG:

ohmygod_smile ohmygod_smile ohmygod_smile LEV - I mean LEV! :lol:

sorry about that! thankfully Carl reminded me .. . :-D
 
I hope you get some rest tonight and can start with a fresh eye tomorrow. Even though we don't want our kitties in pink, sometimes we just need to get some sleep and let it be.

I think raising his dose after every four cycles is safe but still aggressive.
 
Thanks Marje and Julie. It's easier when he feels good. I wish he could just be blue all the time. Wouldn't that be easy?

And thanks for stopping by Mariko.
 
julie & punkin (ga) said:
if you're tired, take it as a gift and let the Lantus do its thing while you catch up on sleep! :YMHUG:

ohmygod_smile ohmygod_smile ohmygod_smile LEV - I mean LEV! :lol:

sorry about that! thankfully Carl reminded me .. . :-D
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ohmygosh - and then i edited instead of quoting.

shoot me now. maybe I should go to bed before i make a worse mistake! :shock:
 
donaleen and Ozy said:
Thank you Julie and Carl for your EXCELLENT reading comprehension. Here I was feeling like a slacker because I want to go to bed.
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Donaleen,
My reading comprehension is pretty good, since I'm not the one losing sleep dealing with a puzzle like Ozy. I can't really help much with IAA or Lev since I have no first hand experience with either. I do try to follow along when I can though. I might not say much but I'm back here cheering you on during the good days and wishing they were all good days.
And somehow, I can't see anybody who's been following you and Ozy ever considering the word "slacker".

Get some sleep, hon. Scritches to Ozy.
Hugs,
Carl
 
Apologies for the delay checking back here - one of our civies has been unwell the past few days and shes keeping me hopping. . . :cool:

PMPS 301 - Looks like Ozy made the R decision for you.

donaleen and Ozy said:
I was hoping he would react to 7 units on the first dose like he did 6.5 units on the first dose just 4 days ago.
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I'd be surprised to see action from a new dose increase on the first cycle. Depot resizing is taking place.

However, I will say that with BKs IAA I always wondered about antibodies periodically releasing bound insulin and how it affected the cycles. I'm not talking about the big 'watch out' release that could potentially happen when IAA breaks, but rather a certain ebb and flow that is different with an IAA kitty. I don't think antibody development is synchronized so that every single antibody develops at the same time and that they all stay active for XXX number of days or months and then all give up in unison. There must be those that come and go during the course of active IAA, separate from 'the pack' and I wonder how whatever bound insulin they release affects things. I truly believe they do .

I wonder what action Ozy will see on cycle 2????? Fingers crossed.

Have a good night :cool:
 
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