1/20 Zoot! AMPS=258; +5.5=312; +10=272; PMPS=211; +3=300

Cinnie Cole

Cinnie Cole

Member Since 2019
After the failed trial (drat) he is back on .25 unit of Lantus. Started last night and again this AM. This AM he was more alert and calm. We will see how we do at this low dose.

So I understand there is no depot at the moment - how would that affect him?

Thanks to all who helped navigate his trial. Even though it was not a success, maybe it did tell us that his pancreas does work, but just needs a bit of help.
 
There are any number of insulins that are available. Most of the other varieties of insulin are what we refer to as "in and out" and most have a shorter duration than Lantus or Levemir. One of the primary differences between those insulins is that Lantus and Lev are depot-type of insulin vs "in and out."

To the point of your question, the depot conveys particular desirable properties to insulin. It provides longer duration and overlap between cycles which, ultimately, flattens out the curve. Typically, once a cat is in good numbers, you see lots and lots of green with much less worry that your cat will plummet into very low numbers. (That's what I meant by flattening out the curve.) Until Zoot's depot is in place, you may not see these properties.

Looking back over Zoot's SS, and no disrespect to your vet, it might be helpful if you didn't rush an OTJ trial. If you have a chance to look at a spreadsheet from a kitty with a successful trial, you'll have a better sense of how we taper back the dose in order to give the pancreas as much support as possible. This is Charlotte's SS -- look at Sheet 1 for an example.
 
Sienne and Gabby (GA) said:
There are any number of insulins that are available. Most of the other varieties of insulin are what we refer to as "in and out" and most have a shorter duration than Lantus or Levemir. One of the primary differences between those insulins is that Lantus and Lev are depot-type of insulin vs "in and out."

To the point of your question, the depot conveys particular desirable properties to insulin. It provides longer duration and overlap between cycles which, ultimately, flattens out the curve. Typically, once a cat is in good numbers, you see lots and lots of green with much less worry that your cat will plummet into very low numbers. (That's what I meant by flattening out the curve.) Until Zoot's depot is in place, you may not see these properties.

Looking back over Zoot's SS, and no disrespect to your vet, it might be helpful if you didn't rush an OTJ trial. If you have a chance to look at a spreadsheet from a kitty with a successful trial, you'll have a better sense of how we taper back the dose in order to give the pancreas as much support as possible. This is Charlotte's SS -- look at Sheet 1 for an example.
Click to expand...
Yeah I agree it happened quickly, but honestly we were starting to deal with low numbers and maybe were overly optimistic. Thanks for the explanation.
 
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