Hmmm, that's a bit puzzling.
Could be she saw some blue #s overnight and now her liver is protesting a bit. If she saw good #s overnight though, I would think she would be feeling better, rather than hanging by the water bowl.
Could be this dose is actually too high, but since you didn't get good results on the lower doses, not sure that lowering it back down is a good idea either. I suppose you could try 1.5u, but I'm not sure there's any real value in doing that.
If you get a PS tonight that is a drop down into lower #s, my guess would be this dose was too high, and then I might try 1.5u. If the PS is about in line with these #s, I'd probably give this dose a little longer, and try to get maybe a bedtime check in to see if maybe she is hitting blues.
An alternate idea is to go back to a lower dose, like one where you got some blues before, but then plan to regularly shoot earlier than at +12 if needed to head off higher #s. That's a pretty stressful route though, so personally I wouldn't go there for the moment at least.
Sorry not to have better advice - I'm a bit stumped. Hopefully some others will chime in with more insight.